State Key Laboratory of Agricultural Microbiology and Provincial Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Colney Lane, Norwich,, NR4 7UH, UK.
New Phytol. 2021 May;230(4):1329-1335. doi: 10.1111/nph.17207. Epub 2021 Feb 10.
Glycosylation is a conserved set of post-translational modifications that exists in all eukaryotic cells. During the last decade, the role of glycosylation in plant pathogenic fungi has received significant attention and considerable progress has been made especially in Ustilago maydis and Magnaporthe oryzae. Here, we review recent advances in our understanding of the role of N-glycosylation, O-glycosylation and glycosylphosphatidylinositol (GPI) anchors during plant infection by pathogenic fungi. We highlight the roles of these processes in regulatory mechanisms associated with appressorium formation, host penetration, biotrophic growth and immune evasion. We argue that improved knowledge of glycosylation pathways and the impact of these modifications on fungal pathogenesis is overdue and could provide novel strategies for disease control.
糖基化是一种普遍存在于所有真核细胞中的翻译后修饰，在过去的十年中，糖基化在植物病原真菌中的作用受到了极大的关注，在玉米黑粉菌和稻瘟病菌方面取得了相当大的进展。在这里，我们综述了近年来我们对 N-糖基化、O-糖基化和糖基磷脂酰肌醇（GPI）锚在病原真菌侵染植物过程中的作用的理解的进展。我们强调了这些过程在与附着胞形成、宿主穿透、生物营养生长和免疫逃避相关的调控机制中的作用。我们认为，糖基化途径及其修饰对真菌发病机制的影响的相关知识亟待完善，这可能为疾病控制提供新的策略。
