Alimohammadi Mahdieh, Aghli Yasaman, Fakhraei Omid, Moradi Ali, Passandideh-Fard Mohammad, Ebrahimzadeh Mohammad Hossein, Khademhosseini Ali, Tamayol Ali, Mousavi Shaegh Seyed Ali
Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Mechanical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
ACS Biomater Sci Eng. 2020 Aug 10;6(8):4356-4376. doi: 10.1021/acsbiomaterials.0c00201. Epub 2020 Jul 17.
Tendon injuries are frequent, and surgical interventions toward their treatment might result in significant clinical complications. Pretendinous adhesion results in the disruption of the normal gliding mechanism of a damaged tendon, painful movements, and an increased chance of rerupture in the future. To alleviate postsurgical tendon-sheath adhesions, many investigations have been directed toward the development of repair approaches using electrospun nanofiber scaffolds. Such methods mainly take advantage of nanofibrous membranes (NFMs) as physical barriers to prevent or minimize adhesion of a repaired tendon to its surrounding sheath. In addition, these nanofibers can also locally deliver antiadhesion and anti-inflammatory agents to reduce the risk of tendon adhesion. This article reviews recent advances in the design, fabrication, and characterization of nanofibrous membranes developed to serve as (i) biomimetic tendon sheaths and (ii) physical barriers. Various features of the membranes are discussed to present insights for further development of repair methods suitable for clinical practice.
肌腱损伤很常见，针对其治疗的手术干预可能会导致严重的临床并发症。腱周粘连会破坏受损肌腱的正常滑动机制，导致运动疼痛，并增加未来再次断裂的几率。为了减轻术后肌腱鞘粘连，许多研究致力于开发使用电纺纳米纤维支架的修复方法。此类方法主要利用纳米纤维膜（NFMs）作为物理屏障，以防止或减少修复后的肌腱与其周围腱鞘的粘连。此外，这些纳米纤维还可以局部递送抗粘连和抗炎剂，以降低肌腱粘连的风险。本文综述了为用作（i）仿生肌腱鞘和（ii）物理屏障而开发的纳米纤维膜在设计、制造和表征方面的最新进展。讨论了这些膜的各种特性，为进一步开发适用于临床实践的修复方法提供见解。
