Lee Eun Mi, Lee Jiyeon, Kim Yejin, Yi Kyung Sik, Cho Janggeun, Kim Jaehoon, An Jong Min, Lee Dahae, Kim Sung Joon, An Eunkyung, Hong Yoo Jin, Jo Hyejung, Lee Seo Hyeon, Jung Yuna, Choi Chi-Hoon, Kang Jae Seung, Hur Jin, Kim Dokyoung
Department of Radiology, Chungbuk National University, Hospital, and Chungbuk National University College of Medicine and Medical Research Institute, Cheongju-si 28644, Republic of Korea.
ACS Biomater Sci Eng. 2020 Aug 10;6(8):4390-4396. doi: 10.1021/acsbiomaterials.0c00611. Epub 2020 Jun 27.
A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed and applied for the computed tomography (CT) scanning of the lungs as an image-guided localization agent. We confirmed the grafting of AgNPs on oxidized pSiMPs template using various analytical equipment, including a scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). The hybrid composite showed a high CT contrast intensity (>1000 HU) that enabled us to produce and view images of the lungs. In addition, it showed the ability to maintain a strong CT signal at the injected area of the rabbit's lungs, up to an hour, without spreading. The lack of toxicity and immune response indicated that the composite could be fully utilized as a new image-guided localization agent of CT scans for lung cancer surgery.
开发了一种银纳米颗粒（AgNPs）与多孔硅微粒（pSiMPs）的混合复合材料，并将其作为图像引导定位剂应用于肺部的计算机断层扫描（CT）。我们使用包括扫描电子显微镜（SEM）、傅里叶变换红外（FTIR）光谱、X射线衍射（XRD）和能量色散X射线光谱（EDS）在内的各种分析设备，证实了AgNPs在氧化的pSiMPs模板上的接枝。该混合复合材料显示出高CT对比强度（>1000 HU），这使我们能够生成并查看肺部图像。此外，它显示出在兔肺注射区域保持强烈CT信号长达一小时而不扩散的能力。缺乏毒性和免疫反应表明，该复合材料可充分用作肺癌手术CT扫描的新型图像引导定位剂。
