Advanced Technology Development Centre, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India.
Department of Mechanical Engineering, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India.
ACS Biomater Sci Eng. 2020 Sep 14;6(9):4748-4773. doi: 10.1021/acsbiomaterials.0c00678. Epub 2020 Aug 17.
Recently, there is a growing interest in developing magnesium (Mg) based degradable biomaterial. Although corrosion is a concern for Mg, other physical properties, such as low density and Young's modulus, combined with good biocompatibility, lead to significant research and development in this area. To address the issues of corrosion and low yield strength of pure Mg, several approaches have been adopted, such as, composite preparation with suitable bioactive reinforcements, alloying, or surface modifications. This review specifically focuses on recent developments in Mg-based metal matrix composites (MMCs) for biomedical applications. Much effort has gone into finding suitable bioactive, bioresorbable reinforcements and processing techniques that can improve upon existing materials. In summary, this review provides a comprehensive overview of existing Mg-based composite preparation and their mechanical and corrosion properties and biological responses and future perspectives on the development of Mg-based composite biomaterials.
最近,人们对开发基于镁 (Mg) 的可降解生物材料越来越感兴趣。虽然腐蚀是镁的一个关注点,但其他物理性质,如低密度和杨氏模量,加上良好的生物相容性,导致了该领域的大量研究和开发。为了解决纯镁腐蚀和屈服强度低的问题,已经采用了几种方法,例如,用合适的生物活性增强材料制备复合材料、合金化或表面改性。本文专门重点介绍了用于生物医学应用的基于镁的金属基复合材料 (MMC) 的最新进展。人们付出了很大的努力来寻找合适的生物活性、可生物吸收的增强材料和加工技术,以改进现有材料。总之,本文综述了现有的基于镁的复合材料的制备及其力学和腐蚀性能以及生物反应,并对基于镁的复合材料生物材料的发展前景进行了展望。