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他克莫司诱导的牙龈增生的罕见现象。

Rare phenomena of tacrolimus-induced gingival hyperplasia.

作者信息

Nivethitha K, Ramesh Amitha, Talwar Avaneendra, Shenoy Nina

机构信息

Department of Periodontics, A B Shetty Memorial Institute of Dental Sciences, Mangaluru, Karnataka, India.

出版信息

J Oral Maxillofac Pathol. 2020 May-Aug;24(2):403. doi: 10.4103/jomfp.JOMFP_50_20. Epub 2020 Sep 9.

DOI:10.4103/jomfp.JOMFP_50_20
PMID:33456264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7802848/
Abstract

In the modern world, men and women are very much concerned about their esthetic appearance. The gingival perspective of esthetics is more often concerned with the soft tissue envelope surrounding the teeth. Gingival enlargement/overgrowth is numerous in nature and often poses a clinical challenge by altering the function, resulting in poor oral health of an individual. Tacrolimus, an immunosuppressive drug, has been broadly used for organ-transplant rejection. It results in much less severe hypertension, hypertrichosis and gingival overgrowth compared to cyclosporine and calcium channel blocker-induced gingival enlargements. However, there is scanty literature available regarding the tacrolimus-induced gingival enlargements. Therefore, the present case report with a 6-month follow-up period describes the execution of the proper treatment plan and surgical protocol for the management of a severe case of generalized gingival enlargement attributed to tacrolimus-induced therapy following renal transplant.

摘要

在现代社会，男性和女性都非常关注自己的美观。美学中的牙龈视角更多地关注围绕牙齿的软组织包膜。牙龈增大/过度生长的情况多种多样，并且常常通过改变功能对临床治疗构成挑战，导致个体口腔健康不佳。他克莫司是一种免疫抑制药物，已广泛用于器官移植排斥反应。与环孢素和钙通道阻滞剂引起的牙龈增大相比，它导致的高血压、多毛症和牙龈过度生长要轻得多。然而，关于他克莫司引起的牙龈增大的文献却很少。因此，本病例报告进行了6个月的随访，描述了针对肾移植后因他克莫司诱导治疗导致的严重广泛性牙龈增大病例实施的适当治疗方案和手术规程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/ecbcd37abb78/JOMFP-24-403b-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/14f04d81445c/JOMFP-24-403b-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/287769c87b70/JOMFP-24-403b-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/4e6e99021132/JOMFP-24-403b-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/9048c83d333a/JOMFP-24-403b-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/9ea6fa5db475/JOMFP-24-403b-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/ecbcd37abb78/JOMFP-24-403b-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/14f04d81445c/JOMFP-24-403b-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/287769c87b70/JOMFP-24-403b-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/4e6e99021132/JOMFP-24-403b-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/9048c83d333a/JOMFP-24-403b-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/9ea6fa5db475/JOMFP-24-403b-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0b/7802848/ecbcd37abb78/JOMFP-24-403b-g006.jpg

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[Surgical correction of excessive gingival enlargements. Case studies].[牙龈过度增生的外科矫正。病例研究]
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本文引用的文献

1
Gingival enlargement among renal transplant recipients in the era of new-generation immunosuppressants.新一代免疫抑制剂时代肾移植受者的牙龈增生
J Periodontol. 2008 Mar;79(3):453-60. doi: 10.1902/jop.2008.070434.
2
Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin A therapy.心脏移植患者接受环孢素A治疗后龈下和唾液微生物群与牙龈增生的关系。
J Periodontol. 2004 Jul;75(7):918-24. doi: 10.1902/jop.2004.75.7.918.
3
Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus.
用于心脏再肌化研究的大型动物模型：方法学综述。
Front Cardiovasc Med. 2023 Mar 15;10:1011880. doi: 10.3389/fcvm.2023.1011880. eCollection 2023.
4
Potential Effect of Giant Freshwater Prawn Shell Nano Chitosan in Inhibiting the Development of and Biofilm .巨型淡水虾壳纳米壳聚糖在抑制[具体生物名称1]和[具体生物名称2]生物膜形成中的潜在作用
Int J Dent. 2023 Feb 10;2023:8890750. doi: 10.1155/2023/8890750. eCollection 2023.
通过用他克莫司替代环孢素A来减少肾移植患者严重的牙龈过度生长。
J Periodontol. 2000 Oct;71(10):1630-6. doi: 10.1902/jop.2000.71.10.1630.
4
Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation.他克莫司。其在器官移植管理中的药理学及临床疗效的最新进展。
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J Am Dent Assoc. 1965 Dec;71(6):1447-50. doi: 10.14219/jada.archive.1965.0019.
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Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers.环孢素A最初作为唯一的免疫抑制剂应用于34例尸体器官接受者：32例肾移植、2例胰腺移植和2例肝移植。
Lancet. 1979 Nov 17;2(8151):1033-6. doi: 10.1016/s0140-6736(79)92440-1.