Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China.
Department of Geriatrics, Jiangsu Provincial Key Laboratory of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Int J Med Sci. 2021 Jan 1;18(4):1024-1029. doi: 10.7150/ijms.46421. eCollection 2021.
With the increasingly serious problem of environmental pollution, the health problems caused by PM2.5 are gradually coming into our line of sight. Previous researches have indicated that air pollution is nearly related to various diseases, but few studies have focused on the exact function mediated by particulate matter less than 2.5 (PM2.5) in these diseases. PM2.5 is known to induce multiple ways of cell death, including autophagy, necrosis, apoptosis, pyroptosis and ferroptosis. Therefore, it is of much importance to understand the different ways of cell death caused by PM2.5 in the pathogenesis and treatment of PM2.5-related diseases. This present review is an insight of multiple ways of PM2.5‑induced cell death in different diseases.
随着环境污染问题的日益严重，由 PM2.5 引起的健康问题逐渐引起了我们的关注。先前的研究表明，空气污染与各种疾病都有密切的关系，但很少有研究关注这些疾病中直径小于 2.5 微米的颗粒物（PM2.5）具体介导的作用。PM2.5 已知会引起多种细胞死亡方式，包括自噬、坏死、凋亡、细胞焦亡和铁死亡。因此，了解 PM2.5 引起的不同细胞死亡方式在 PM2.5 相关疾病的发病机制和治疗中的作用非常重要。本综述深入探讨了 PM2.5 在不同疾病中诱导细胞死亡的多种方式。
