Ratna Sudha M, Neelamraju Jayanthi, Surendra Reddy M, Kumar Manoj
Centre for Research and Development, Unique Biotech Ltd., Plot No. 2, Phase-II, Alexandria Knowledge Park, Hyderabad, Telangana 500 078, India.
Department of Pedodontics and Preventive Dentistry, SVS Institute of Dental Sciences, Mahbubnagar, Telangana, India.
Int J Dent. 2020 Dec 29;2020:8891708. doi: 10.1155/2020/8891708. eCollection 2020.
Probiotic organisms are known to reduce caries causing microorganisms and . . To evaluate the effect of probiotic Unique IS2 on mutans streptococci and lactobacilli levels in saliva and plaque in children.
Dental caries or tooth decay is because of the demineralization of the tooth enamel leading to the breakdown of the enamel causing cavities to be formed. Demineralization of the tooth happens because of the acid secreted by bacteria like and . It is now suggested that probiotic usage prevents the overgrowth of these pathogenic microbes, thereby reducing caries activity. . In this double-blind, randomized, placebo-controlled study, 48 children with ages ranging from 5 to 15 years were divided into two groups, the probiotic and placebo groups. Chewable tablets with and without probiotic Unique IS2 were administered for two weeks. Stimulated saliva samples and plaque were collected at baseline and at the end of 14 days to measure the pH, and count of saliva and plaque using chairside kits.
A statistically significant reduction in and counts of both saliva and plaque samples was observed in the . Unique IS2 treated group after 14 days of administration compared to the baseline and placebo group (using paired -test).
Probiotic Unique IS2 (2 billion cfu) chewable tablet is effective in reduction and inhibition of caries causing and levels in saliva and plaque in children.
已知益生菌可减少致龋微生物……以评估益生菌Unique IS2对儿童唾液和牙菌斑中变形链球菌和乳酸菌水平的影响。
龋齿或蛀牙是由于牙釉质脱矿导致牙釉质破坏并形成龋洞。牙齿脱矿是由变形链球菌和乳酸菌等细菌分泌的酸引起的。现在有人提出使用益生菌可防止这些致病微生物过度生长，从而降低龋齿活性。……在这项双盲、随机、安慰剂对照研究中，48名年龄在5至15岁的儿童被分为两组，即益生菌组和安慰剂组。分别给予含和不含益生菌Unique IS2的咀嚼片，为期两周。在基线和第14天结束时收集刺激唾液样本和牙菌斑，使用椅旁试剂盒测量唾液和牙菌斑的pH值、变形链球菌和乳酸菌计数。
与基线和安慰剂组相比，服用Unique IS2的治疗组在给药14天后，唾液和牙菌斑样本中的变形链球菌和乳酸菌计数均有统计学意义的显著降低（使用配对t检验）。
益生菌Unique IS2（20亿cfu）咀嚼片可有效降低和抑制儿童唾液和牙菌斑中致龋的变形链球菌和乳酸菌水平。
