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制药行业的价值体系与定价:丙型肝炎的金融资本通胀与疟疾药物创新及生产资本节约

Value regimes and pricing in the pharmaceutical industry: financial capital inflation (hepatitis C) versus innovation and production capital savings for malaria medicines.

作者信息

Cassier Maurice

机构信息

Cermes3, 7 rue Guy Moquet, 94801 Villejuif Cedex, Paris, France.

出版信息

Biosocieties. 2021;16(3):323-341. doi: 10.1057/s41292-020-00214-4. Epub 2021 Jan 13.

DOI:10.1057/s41292-020-00214-4
PMID:33456494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7803660/
Abstract

The idea of this paper is to draw a parallel between two diametrically opposed political economies of medicine that coexist today. The first is embodied in the invention, appropriation, and distribution of antivirals for hepatitis C, particularly sofosbuvir, which was commercialized at an initial price of $85,000 in the United States, €56,000 in France, and $8000 in Brazil. These prices destabilized payers in both the North and the South. The second economy encompasses the invention, industrialization and distribution of new therapeutic combinations for malaria that were commercialized by Sanofi from 2007 onwards at a price of $1 per treatment for public markets. This price was set by a contract negotiated with Médecins sans Frontières. In this paper, I examine the pricing of these 2 classes of drugs, and I argue that the prices synthesize these political economies: they summarize the policy of appropriation of these molecules, aimed at their monopolization or a model of common good; they are referred to economic value regimes designed to optimize the profitability of advanced capital or to increase the accessibility of drugs for public payers and patients; and they are justified or contested by moral economies.

摘要

本文的主旨是对当今并存的两种截然不同的医学政治经济学进行对比。第一种体现在丙型肝炎抗病毒药物的发明、专利获取及销售方面,尤其是索非布韦,其在美国的初始售价为8.5万美元,在法国为5.6万欧元,在巴西为8000美元。这些价格令南北两方的支付方都感到不安。第二种经济模式涵盖了疟疾新治疗组合的发明、产业化及销售,赛诺菲自2007年起将其推向公共市场,每次治疗收费1美元。这个价格是通过与无国界医生组织协商的合同确定的。在本文中,我研究了这两类药物的定价,并认为价格综合了这些政治经济学因素:它们总结了对这些药物分子的专利获取政策,旨在实现垄断或追求公益模式;它们参考了旨在优化先进资本盈利能力或提高公共支付方及患者药物可及性的经济价值体系;它们基于道德经济而得到正当性辩护或受到质疑。

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本文引用的文献

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New business models for research and development with affordability requirements are needed to achieve fair pricing of medicines.为实现药品公平定价,需要具备可承受性要求的新型研发商业模式。
BMJ. 2020 Jan 13;368:l4408. doi: 10.1136/bmj.l4408.
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Rethinking in the Bio-economy: Finance, Assetization, and the Management of Value.生物经济中的反思:金融、资产化与价值管理
Sci Technol Human Values. 2017 May;42(3):460-490. doi: 10.1177/0162243916661633. Epub 2016 Aug 10.
3
The Pharmaceutical Commons: Sharing and Exclusion in Global Health Drug Development.药品共享库:全球卫生药品研发中的共享与排斥
Sci Technol Human Values. 2015 Jan;40(1):3-29. doi: 10.1177/0162243914542349.
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The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts.慢性髓性白血病(CML)药物的价格反映了癌症药物的不可持续价格:从一大群 CML 专家的角度来看。
Blood. 2013 May 30;121(22):4439-42. doi: 10.1182/blood-2013-03-490003. Epub 2013 Apr 25.
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The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership.青蒿琥酯/阿莫地喹口服制剂的初步药物开发用于疟疾治疗:公私合作伙伴关系。
Malar J. 2011 May 23;10:142. doi: 10.1186/1475-2875-10-142.
6
Brave new industry, that has such patents in it! Reflections on the economic consequences of patenting DNA.多么新兴的行业啊,里面竟然有这样的专利!关于DNA专利的经济后果的思考。
Adv Genet. 2003;50:385-98; discussion 507-10. doi: 10.1016/s0065-2660(03)50020-7.