Wang Ruixue, Luo Xiaoshan, Liu Fang, Luo Shuhong
Department of Basic Medicine and Biomedical Engineering, School of Stomatology and Medicine, Foshan University, Foshan, Guangdong 528000, P.R. China.
Department of Laboratory Medicine, School of Stomatology and Medicine, Foshan University, Foshan, Guangdong 528000, P.R. China.
Exp Ther Med. 2021 Feb;21(2):155. doi: 10.3892/etm.2020.9587. Epub 2020 Dec 17.
The novel coronavirus (SARS-CoV-2) appeared in2019 in Wuhan, China, and rapidly developed into a global pandemic. The disease has affected not only health care systems and economies worldwide but has also changed the lifestyles and habits of the majority of the world's population. Among the potential targets for SARS-CoV-2 therapy, the viral spike glycoprotein has been studied most intensely, due to its key role in mediating viral entry into target cells and inducing a protective antibody response in infected individuals. In the present manuscript the molecular mechanisms that are responsible for SARS-CoV-2 infection are described and a progress report on the status of SARS-CoV-2 research is provided. A brief review of the clinical symptoms of the condition and current diagnostic methods and treatment plans for SARS-CoV-2 are also presented and the progress of preclinical research into medical intervention against SARS-CoV-2 infection are discussed.
新型冠状病毒（SARS-CoV-2）于2019年在中国武汉出现，并迅速发展成为全球大流行疾病。该疾病不仅影响了全球的医疗保健系统和经济，还改变了世界上大多数人口的生活方式和习惯。在SARS-CoV-2治疗的潜在靶点中，病毒刺突糖蛋白因其在介导病毒进入靶细胞以及在受感染个体中诱导保护性抗体反应方面的关键作用而受到了最深入的研究。在本手稿中，描述了导致SARS-CoV-2感染的分子机制，并提供了SARS-CoV-2研究现状的进展报告。还简要回顾了该疾病的临床症状以及SARS-CoV-2的当前诊断方法和治疗方案，并讨论了针对SARS-CoV-2感染的医学干预的临床前研究进展。
