Wang Jiankun, Wang Min, Zhao Lili, Liu Li, Wang Xiang, Fan Zhining
Digestive Endoscopy Department and General Surgery Department, The First Affiliated Hospital with Nanjing Medical University and Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China.
Exp Ther Med. 2021 Feb;21(2):160. doi: 10.3892/etm.2020.9591. Epub 2020 Dec 18.
Mineral smectite granules have traditionally been used for diarrhea and gastrointestinal bleeding; however, the wound healing ability of mineral smectite granules has not been investigated in detail. Therefore, the present study explored the efficacy and safety of mineral smectite granules on wound healing. An excision wound rat model was established. The experimental group was treated with smectite granules, the positive control group was treated with starch and the blank control group was left untreated. Wound closure rates, wound healing times and histopathological analysis were compared among the three groups. The mechanism underlying the effects of mineral smectite granules on wound healing was assessed by performing picrosirius red staining and immunohistochemical staining and measuring hydroxyproline content. Based on wound closure rates, wound healing times and histopathological analysis, the results indicated that rats treated with smectite granules displayed increased wound healing efficacy compared with the other two groups. Investigation of the underlying mechanism suggested that mineral smectite granules could promote wound healing by inducing collagen fiber synthesis and increasing the number of neovessels. The present study indicated the efficacy and safety of mineral smectite granules on wound healing and provided a theoretical basis for its application in a clinical setting.
蒙脱石颗粒传统上用于治疗腹泻和胃肠道出血；然而，蒙脱石颗粒的伤口愈合能力尚未得到详细研究。因此，本研究探讨了蒙脱石颗粒对伤口愈合的疗效和安全性。建立了切除伤口大鼠模型。实验组用蒙脱石颗粒治疗，阳性对照组用淀粉治疗，空白对照组不进行治疗。比较三组的伤口闭合率、伤口愈合时间和组织病理学分析。通过进行天狼星红染色和免疫组织化学染色以及测量羟脯氨酸含量来评估蒙脱石颗粒对伤口愈合影响的潜在机制。基于伤口闭合率、伤口愈合时间和组织病理学分析，结果表明，与其他两组相比，用蒙脱石颗粒治疗的大鼠伤口愈合效果增强。对潜在机制的研究表明，蒙脱石颗粒可通过诱导胶原纤维合成和增加新血管数量来促进伤口愈合。本研究表明了蒙脱石颗粒对伤口愈合的疗效和安全性，并为其在临床环境中的应用提供了理论依据。
