Department of Surgery, College of Medicine, University of Mosul, Mosul, Iraq.
Department of Pharmacology, College of Pharmacy, University of Mosul, Mosul, Iraq.
J Med Life. 2020 Oct-Dec;13(4):463-468. doi: 10.25122/jml-2020-0015.
Allergic rhinitis (AR) is a type of inflammatory condition that includes a group of symptoms, mainly affecting the nasal mucosa. Nasal obstruction, sneezing, stuffy or runny nose, in addition to swollen, itchy, red and watery eyes are the most common symptoms of the disease. These symptoms are triggered as a result of increased inflammatory mediators such as histamine and leukotrienes. Studies have recently shown the role of vitamin D (vit.D) in many allergic and immune conditions, where receptors for the active form of vit.D (1,25-dihydroxyvitamin D3) have been discovered on the surface of almost all types of inflammatory cells. Therefore, the present study was conducted to explore the level of vit. D in AR patients and its correlation with the severity of the disease. Two groups participated in the study; the first group included 49 patients who were diagnosed in a private otolaryngology clinic by the first author as having allergic rhinitis (AR group). The second one served as a control group and included 50 apparently healthy volunteers with no history of AR. The mean level of IgE and vit. D was found to be 326.3 and 10.2 ng/ml in the AR group, respectively, and 30.8 and 23.3 ng/ml in the control group, respectively. Ninety-three percent of AR patients have shown a deficiency in vit. D level, where 56% of this group showed severe deficiency. On the other hand, 34% of the control group has shown an insufficient level of vit. D. Additionally, 64% of AR patients have shown serum levels of IgE at values ranging between 100-299 ng/ml. Higher serum levels of IgE at values ranging between 300-599 ng/ml and 600-1000 ng/ml were observed in 25% and 11% of AR patients, respectively. The prevalence of low levels of vit. D in the AR group was significantly higher than that in the control group (P < 0.001). Vit. D deficiency is significantly related to severe AR symptoms and measuring serum vit. D level is recommended in the management plan of this group of patients.
变应性鼻炎（AR）是一种炎症性疾病，包括一组症状，主要影响鼻黏膜。鼻塞、打喷嚏、鼻塞或流鼻涕，以及肿胀、瘙痒、红肿和水汪汪的眼睛是该疾病最常见的症状。这些症状是由于炎症介质（如组胺和白三烯）增加而引起的。最近的研究表明，维生素 D（vit.D）在许多过敏和免疫疾病中发挥作用，在几乎所有类型的炎症细胞表面都发现了活性形式的 vit.D（1,25-二羟维生素 D3）的受体。因此，本研究旨在探讨 AR 患者 vit.D 水平及其与疾病严重程度的相关性。两组参与了这项研究；第一组包括 49 名患者，由第一作者在一家私人耳鼻喉科诊所诊断为变应性鼻炎（AR 组）。第二组作为对照组，包括 50 名无 AR 病史的健康志愿者。AR 组的 IgE 和 vit.D 平均水平分别为 326.3 和 10.2ng/ml，对照组分别为 30.8 和 23.3ng/ml。93%的 AR 患者显示 vit.D 水平缺乏，其中 56%的患者表现为严重缺乏。另一方面，对照组的 34%显示 vit.D 水平不足。此外，64%的 AR 患者的 IgE 血清水平在 100-299ng/ml 之间。在 AR 患者中，分别有 25%和 11%的患者观察到 300-599ng/ml 和 600-1000ng/ml 之间的 IgE 血清水平较高。AR 组 vit.D 水平较低的患病率明显高于对照组（P<0.001）。vit.D 缺乏与严重的 AR 症状显著相关，建议在该组患者的管理计划中测量血清 vit.D 水平。
