• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Pharmacokinetics in sepsis.脓毒症中的药代动力学
BJA Educ. 2019 Jan;19(1):7-13. doi: 10.1016/j.bjae.2018.09.006. Epub 2018 Nov 9.
2
Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock.治疗脓毒症和脓毒性休克患者时的药代动力学和药效学考量
Clin Pharmacokinet. 2002;41(14):1135-51. doi: 10.2165/00003088-200241140-00002.
3
Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat.败血症早期头孢曲松药代动力学/药效学的变化:一项在大鼠身上进行的前瞻性实验研究。
J Transl Med. 2016 Nov 15;14(1):316. doi: 10.1186/s12967-016-1072-9.
4
Population pharmacokinetics/pharmacodynamics of linezolid in sepsis patients with and without continuous renal replacement therapy.利奈唑胺在伴有和不伴有连续肾脏替代治疗的脓毒症患者中的群体药代动力学/药效学。
Int J Antimicrob Agents. 2018 May;51(5):745-751. doi: 10.1016/j.ijantimicag.2018.01.021. Epub 2018 Feb 6.
5
Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis.液体转移对患有腹腔内脓毒症的重症监护患者的环丙沙星药代动力学没有影响。
Int J Antimicrob Agents. 2005 Jul;26(1):50-5. doi: 10.1016/j.ijantimicag.2005.04.005.
6
Evaluation of Amikacin Pharmacokinetics in Critically Ill Patients with Intra-abdominal Sepsis.腹腔内脓毒症重症患者阿米卡星药代动力学评估
Adv Pharm Bull. 2020 Jan;10(1):114-118. doi: 10.15171/apb.2020.014. Epub 2019 Dec 11.
7
Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis.重组人活化蛋白C在儿童严重脓毒症中的安全性、药代动力学及药效学研究
Pediatrics. 2004 Jan;113(1 Pt 1):7-17. doi: 10.1542/peds.113.1.7.
8
Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?万古霉素群体药代动力学在脓毒症或感染性休克成人患者中的应用:目前的给药方案是否足够?
Eur J Clin Pharmacol. 2019 Sep;75(9):1219-1226. doi: 10.1007/s00228-019-02694-1. Epub 2019 Jun 1.
9
Population Pharmacokinetics of High-Dose Tigecycline in Patients with Sepsis or Septic Shock.高剂量替加环素在脓毒症或感染性休克患者中的群体药代动力学。
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02273-17. Print 2018 Apr.
10
A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2.一种早期脓毒症大鼠模型:庆大霉素药代动力学与细菌脂多糖联合白细胞介素-2对全身和肾脏影响的关系。
Biol Pharm Bull. 2012;35(10):1703-10. doi: 10.1248/bpb.b12-00205.

引用本文的文献

1
Cannabinoids in preclinical research of sepsis: a scoping review.脓毒症临床前研究中的大麻素:一项范围综述
Inflamm Res. 2025 Sep 16;74(1):125. doi: 10.1007/s00011-025-02090-9.
2
Advancements, Challenges, and Future Prospects of Nanotechnology in Sepsis Therapy.纳米技术在脓毒症治疗中的进展、挑战与未来前景
Int J Nanomedicine. 2025 Jun 16;20:7685-7714. doi: 10.2147/IJN.S488026. eCollection 2025.
3
Anticoagulation in venovenous extracorporeal membrane oxygenation.静脉-静脉体外膜肺氧合中的抗凝
Front Med (Lausanne). 2025 Mar 4;12:1530411. doi: 10.3389/fmed.2025.1530411. eCollection 2025.
4
Pharmacokinetics of Opioid Infusions in the Adult Intensive Care Unit Setting-A Systematic Review.成人重症监护病房中阿片类药物输注的药代动力学——一项系统评价
Clin Pharmacokinet. 2025 Mar;64(3):323-334. doi: 10.1007/s40262-025-01490-8. Epub 2025 Mar 1.
5
Penetration of linezolid and tedizolid in cerebrospinal fluid of mouse and impact of blood-brain barrier disruption.利奈唑胺和替加环素在小鼠脑脊液中的穿透情况及血脑屏障破坏的影响
Clin Transl Sci. 2025 Jan;18(1):e70100. doi: 10.1111/cts.70100.
6
Removal of common antimicrobial agents by sustained low-efficiency dialysis.持续低效透析清除常见抗菌药物。
Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0157923. doi: 10.1128/aac.01579-23. Epub 2024 Feb 13.
7
Therapeutic Drug Monitoring of Voriconazole in Critically Ill Pediatric Patients: A Single-Center Retrospective Study.重症儿科患者伏立康唑的治疗药物监测:一项单中心回顾性研究。
Paediatr Drugs. 2024 Mar;26(2):197-203. doi: 10.1007/s40272-023-00616-4. Epub 2024 Jan 16.
8
Sedation for Patients with Sepsis: Towards a Personalised Approach.脓毒症患者的镇静:迈向个性化治疗方法
J Pers Med. 2023 Nov 24;13(12):1641. doi: 10.3390/jpm13121641.
9
In Vitro Susceptibility Tests in the Context of Antifungal Resistance: Beyond Minimum Inhibitory Concentration in spp.抗真菌耐药背景下的体外药敏试验:超越某菌属的最低抑菌浓度
J Fungi (Basel). 2023 Dec 12;9(12):1188. doi: 10.3390/jof9121188.
10
Extracorporeal blood purification therapies for sepsis-associated acute kidney injury in critically ill patients: expert opinion from the SIAARTI-SIN joint commission.体外血液净化疗法治疗危重症患者脓毒症相关性急性肾损伤:来自 SIAARTI-SIN 联合委员会的专家意见。
J Nephrol. 2023 Sep;36(7):1731-1742. doi: 10.1007/s40620-023-01637-5. Epub 2023 Jul 13.

本文引用的文献

1
Definitions and pathophysiology of vasoplegic shock.血管扩张性休克的定义和病理生理学。
Crit Care. 2018 Jul 6;22(1):174. doi: 10.1186/s13054-018-2102-1.
2
Vasoplegia treatments: the past, the present, and the future.血管扩张治疗:过去、现在和未来。
Crit Care. 2018 Feb 27;22(1):52. doi: 10.1186/s13054-018-1967-3.
3
Incidence, timing and outcome of AKI in critically ill patients varies with the definition used and the addition of urine output criteria.危重症患者急性肾损伤的发病率、发生时间和结局因所采用的定义以及尿量标准的增加而有所不同。
BMC Nephrol. 2017 Feb 20;18(1):70. doi: 10.1186/s12882-017-0487-8.
4
Sugammadex.舒更葡糖钠
Hosp Pharm. 2016 Jul;51(7):585-96. doi: 10.1310/hpj5107-585.
5
Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index.根据休克指数定义,在有休克风险的院外患者中,氯胺酮快速序贯诱导后的血流动力学反应。
Ann Emerg Med. 2016 Aug;68(2):181-188.e2. doi: 10.1016/j.annemergmed.2016.03.041. Epub 2016 Apr 27.
6
The effect of prone positioning with surgical bolsters on liver blood flow in healthy volunteers.手术垫俯卧位对健康志愿者肝血流的影响。
Anaesthesia. 2016 May;71(5):550-5. doi: 10.1111/anae.13416. Epub 2016 Mar 7.
7
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).《脓毒症及脓毒性休克第三次国际共识定义(脓毒症-3)》
JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.
8
Heat effects on drug delivery across human skin.热对药物透过人体皮肤传递的影响。
Expert Opin Drug Deliv. 2016;13(5):755-68. doi: 10.1517/17425247.2016.1136286. Epub 2016 Jan 25.
9
Empiric antimicrobial therapy in severe sepsis and septic shock: optimizing pathogen clearance.严重脓毒症和脓毒性休克的经验性抗菌治疗:优化病原体清除
Curr Infect Dis Rep. 2015 Jul;17(7):493. doi: 10.1007/s11908-015-0493-6.
10
Propofol infusion syndrome in adults: a clinical update.成人丙泊酚输注综合征:临床最新进展
Crit Care Res Pract. 2015;2015:260385. doi: 10.1155/2015/260385. Epub 2015 Apr 12.

Pharmacokinetics in sepsis.

作者信息

Charlton M, Thompson J P

机构信息

University Hospitals of Leicester NHS Trust, Leicester, UK.

University of Leicester, Leicester, UK.

出版信息

BJA Educ. 2019 Jan;19(1):7-13. doi: 10.1016/j.bjae.2018.09.006. Epub 2018 Nov 9.

DOI:10.1016/j.bjae.2018.09.006
PMID:33456848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7807908/
Abstract
摘要