Konda Prathyusha, Lifshits Liubov M, Roque John A, Cole Houston D, Cameron Colin G, McFarland Sherri A, Gujar Shashi
Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada.
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA.
Oncoimmunology. 2020 Dec 29;10(1):1863626. doi: 10.1080/2162402X.2020.1863626.
We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.
我们报告了一类新型的钌（Ru）基光敏剂，其在近红外光激活后可在黑色素瘤细胞中诱导强烈的细胞毒性。除了直接的细胞毒性作用外，这种基于钌的光动力疗法还可诱导黑色素瘤细胞发生免疫原性细胞死亡，这可被用于治疗以建立保护性抗肿瘤免疫。
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