Manckoundia Patrick, Franon Evelyne
Department of Geriatrics and Internal Medicine, Dijon University Hospital, Dijon, France.
UMR Inserm/U1093 Cognition, Action, Sensorimotor Plasticity, University of Burgundy and Franche Comté, Dijon, France.
Eur J Case Rep Intern Med. 2020 Dec 29;7(12):002145. doi: 10.12890/2020_002145. eCollection 2020.
The typical clinical picture of COVID-19 is gradually becoming clearer, both in the acute phase and in the long-term. However, new symptoms are gradually being identified. We describe a long-term symptom that has not yet been reported.
A 49-year-old man consulted for persistent asthenia. The general practitioner found a fever (39.2°C), and COVID-19 was confirmed by the polymerase chain reaction test. Further symptoms appeared, notably thick, white, painless tracheal hypersecretion for 3 months before diminishing, without disappearing.
Non-inflammatory tracheal hypersecretion, not yet reported in COVID-19, may be an additional long-term symptom. The hyperstimulation of tracheal goblet cells secreting mucus is 1 pathophysiological hypothesis.
Painless, non-inflammatory tracheal hypersecretion, which has yet to be described in post-acute COVID-19, may be an additional long-term symptom of the disease.The hyperstimulation of mucus-secreting tracheal goblet cells by the coronavirus, leading to tracheal discomfort and a feeling of suffocation, is 1 pathophysiological hypothesis.
COVID-19的典型临床症状在急性期和长期病程中都逐渐变得更加清晰。然而，新的症状也在逐渐被发现。我们描述一种尚未被报道过的长期症状。
一名49岁男性因持续乏力前来就诊。全科医生发现其发热（39.2°C），经聚合酶链反应检测确诊为COVID-19。随后出现了其他症状，尤其是持续3个月的浓稠、白色、无痛性气管分泌物增多，之后有所减轻但未消失。
非炎性气管分泌物增多这一在COVID-19中尚未被报道的症状，可能是一种额外的长期症状。分泌黏液的气管杯状细胞过度刺激是一种病理生理假设。
无痛性、非炎性气管分泌物增多这一在急性COVID-19后尚未被描述的症状，可能是该疾病的另一种长期症状。冠状病毒对分泌黏液的气管杯状细胞的过度刺激，导致气管不适和窒息感，是一种病理生理假设。
