Department of Gastroenterology, Grigore T. Popa University of Medicine and Pharmacy, Iasi 700115, Romania.
St. Spiridon Emergency Hospital, Iasi 700115, Romania.
Can J Gastroenterol Hepatol. 2020 Dec 29;2020:6630296. doi: 10.1155/2020/6630296. eCollection 2020.
Nonalcoholic fatty liver disease has become the main concern of hepatologists around the world and the main research topic for identifying effective and safe therapy. Advances in the treatment of chronic viral hepatitis in recent years have opened the way towards reducing mortality in patients with chronic liver disease. This goal has not yet been reached, as the burden of chronic liver disease remains a future major health problem as the incidence of the nonalcoholic fatty liver disease continues to rise. The proportion of patients with liver cirrhosis and those with hepatocellular carcinoma due to nonalcoholic liver disease on the liver transplant waiting list has increased in the last years. The upward trend in the incidence and prevalence of the disease in recent decades raises concern over a possible global epidemic, especially as the disease is still underestimated and underdiagnosed. Chronic kidney disease presented an increase in incidence and prevalence during the last years, and it has been associated not only with increased morbidity and mortality but also with high costs for the health system. During the last decade, several studies have shown the association between nonalcoholic fatty disease and chronic kidney disease, two major worldwide health problems.
非酒精性脂肪性肝病已成为全世界肝病学家关注的主要问题，也是寻找有效和安全疗法的主要研究课题。近年来，慢性乙型肝炎治疗方面的进展为降低慢性肝病患者的死亡率开辟了道路。但这一目标尚未实现，因为随着非酒精性脂肪性肝病的发病率持续上升，慢性肝病的负担仍然是未来的一个主要健康问题。在过去几年中，由于非酒精性肝病，肝移植等候名单上的肝硬化和肝细胞癌患者的比例有所增加。近几十年来，该疾病的发病率和流行率呈上升趋势，令人担忧可能出现全球性流行，尤其是因为该病仍然被低估和漏诊。近年来，慢性肾脏病的发病率和患病率也有所上升，而且它不仅与发病率和死亡率的增加有关，还与卫生系统的高成本有关。在过去十年中，有几项研究表明非酒精性脂肪性肝病与慢性肾脏病之间存在关联，这两种疾病都是全球范围内的主要健康问题。
