Zhao Pingping, Yan Junxin, Pan Binjing, Liu Jingfang, Fu Songbo, Cheng Jianguo, Wang Liting, Jing Gaojing, Li Qiong
The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Apr 14;15:1141-1151. doi: 10.2147/DMSO.S356497. eCollection 2022.
To explore the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM).
A total of 1168 patients with T2DM were divided into the non-CKD and CKD groups, and the difference in the prevalence of NAFLD was compared. The differences in serum creatinine (SCr) and urine albumin-to-creatinine ratio (UACR) levels were compared between the non-NAFLD and NAFLD groups. Patients with T2DM were divided into three groups according to their UACR levels (UACR < 30 mg/g [U1 group]; UACR ≤ 30 mg/g to < 300 mg/g [U2 group]; and UACR ≥ 300 mg/g [U3 group]) or estimated glomerular filtration rate (eGFR) levels (≥ 90 mL/min [G1 group]; eGFR ≤ 60 mL/min to < 90 mL/min [G2 group]; and eGFR < 60 mL/min (G3 group]). The difference in the prevalence and risks of NAFLD in the different UACR or eGFR level groups was analyzed.
The prevalence of NAFLD in the CKD group was higher than that in the non-CKD group (63.5% vs 50.5%, < 0.001). The SCr and UACR levels in the NAFLD group were higher than those in the non-NAFLD group (both <0.05). The prevalence of NAFLD in the U3 group (75.6%) was higher than that in the U1 (50.5%, < 0.05) and U2 (60.1%, < 0.05) groups, and the prevalence of NAFLD in the U2 group (60.1%) was higher than that in the U1 group (50.5%, < 0.05). The risk of NAFLD in the U3 group was higher than that in the U2 group (odds ratio [OR] = 3.032 and 1.473). Despite adjusting the parameters further, the NAFLD risk in the U3 group remained higher than that in the U2 group (OR = 1.660 and 2.342).
The risk of NAFLD in patients with T2DM is closely related to CKD.
探讨2型糖尿病（T2DM）患者中非酒精性脂肪性肝病（NAFLD）与慢性肾脏病（CKD）之间的关系。
将1168例T2DM患者分为非CKD组和CKD组，比较NAFLD患病率的差异。比较非NAFLD组和NAFLD组血清肌酐（SCr）和尿白蛋白与肌酐比值（UACR）水平的差异。根据UACR水平（UACR<30mg/g[U1组]；UACR≤30mg/g至<300mg/g[U2组]；UACR≥300mg/g[U3组]）或估计肾小球滤过率（eGFR）水平（≥90mL/min[G1组]；eGFR≤60mL/min至<90mL/min[G2组]；eGFR<60mL/min[G3组]）将T2DM患者分为三组。分析不同UACR或eGFR水平组中NAFLD的患病率和风险差异。
CKD组中NAFLD的患病率高于非CKD组（63.5%对50.5%，<0.001）。NAFLD组的SCr和UACR水平高于非NAFLD组（均<0.05）。U3组中NAFLD的患病率高于U1组（50.5%，<0.05）和U2组（60.1%，<0.05），U2组中NAFLD的患病率高于U1组（50.5%，<0.05）。U3组中NAFLD的风险高于U2组（比值比[OR]=3.032和1.473）。尽管进一步调整了参数，U3组中NAFLD的风险仍高于U2组（OR=1.660和2.34%）。
T2DM患者中NAFLD的风险与CKD密切相关。
