Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan S/N, Toluca, Estado de México, 50180, Mexico.
Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, Ocoyoacac, Estado de México, 52750, Mexico.
Macromol Biosci. 2021 Mar;21(3):e2000362. doi: 10.1002/mabi.202000362. Epub 2021 Jan 18.
Polymeric nanoparticles encompass micelles and dendrimers. They are used for improving or controlling the action of the loaded therapy or imaging agent, including radionuclides. Some radionuclides possess properties appropriate for simultaneous imaging and therapy of a disease and are therefore called theranostic. The diversity in core materials and surface modification, as well as radiolabeling strategies, offers multiples possibilities for preparing polymeric nanoparticles using radionuclides. The present review describes different strategies in the preparation of such nanoparticles and their applications in nuclear nanomedicine.
聚合物纳米粒子包括胶束和树枝状聚合物。它们用于改善或控制负载治疗或成像剂的作用，包括放射性核素。一些放射性核素具有适合同时治疗和成像疾病的特性，因此被称为治疗诊断。核心材料和表面修饰以及放射性标记策略的多样性为使用放射性核素制备聚合物纳米粒子提供了多种可能性。本文综述了制备这些纳米粒子的不同策略及其在核纳米医学中的应用。
