Faculty of Medicine, University of Novi Sad, Novi Sad, Republic of Serbia.
Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Republic of Serbia.
Biorheology. 2020;57(2-4):87-100. doi: 10.3233/BIR-201008.
Numerous functions of saliva depend on its biophysical properties. Mouth rinses react with saliva and change both their own properties and properties of saliva.
The aim of this study was to define the level of mixing of artificial saliva and mouth rinses, and define their viscosity and its changes at room and body temperature.
Artificial saliva, fluoride solutions, chlorhexidine, zinc-hydroxyapatite solution and casein phosphopeptide amorphous calcium phosphate were used. To simulate their mixing, Y-channel PVC chips were used, in two different microfluidics systems. The experiments were recorded with a microscope, then the proportion of mixing was calculated using Matlab. For viscosity measurements rotational viscometer was used.
The results show partial mixing of all solutions with artificial saliva. Measurements with a viscometer indicate different viscosities of all used solutions. Viscosity of a mixture of solution and artificial saliva is always in the range of viscosity of the artificial saliva and the solution separately. Moreover, viscosity of all solutions, as well as mixture with artificial saliva, significantly decreases at higher temperature.
Intraoral administration of mouth rinses results in change of biophysical properties of both saliva and mouth rinses. Those changes can affect preventive and therapeutic effect, and therefore oral health.
唾液具有许多功能，这些功能依赖于其生物物理特性。漱口液与唾液相互作用，改变自身和唾液的特性。
本研究旨在确定人工唾液和漱口液的混合程度，并确定其在室温及体温下的黏度及其变化。
使用人工唾液、氟化物溶液、洗必泰、锌-羟基磷灰石溶液和酪蛋白磷酸肽无定形磷酸钙。使用 Y 型 PVC 芯片模拟它们的混合，在两种不同的微流控系统中进行实验。使用显微镜记录实验，然后使用 Matlab 计算混合比例。使用旋转黏度计测量黏度。
结果表明，所有溶液与人工唾液均发生部分混合。黏度计测量表明，所有使用的溶液均具有不同的黏度。溶液与人工唾液混合物的黏度始终在人工唾液和单独溶液的黏度范围内。此外，所有溶液以及与人工唾液的混合物的黏度在较高温度下显著降低。
口腔内使用漱口液会导致唾液和漱口液的生物物理特性发生变化。这些变化可能会影响预防和治疗效果，从而影响口腔健康。
