Wortis H H
Clin Exp Immunol. 1971 Feb;8(2):305-17.
Mice homozygous for the mutation which lack a thymus, were found to have a marked lymphopenia. They had a marked granulocytosis following administration of , but only slight lymphocytosis. Unlike littermates they failed to develop an increased cellularity of lymph nodes draining a local injection of PHA. They had reduced levels of immunoglobulin but produced some antibody to sheep-RBC. They accepted allografts. Cell cooperation experiments suggest that the immunological deficits of mice can be explained by the absence of a thymusderived cell population.
纯合子突变小鼠无胸腺，发现有明显的淋巴细胞减少。给予[具体物质]后，它们有明显的粒细胞增多，但仅有轻微的淋巴细胞增多。与同窝小鼠不同，它们在局部注射PHA后，引流淋巴结的细胞数量未增加。它们的免疫球蛋白水平降低，但能产生一些抗绵羊红细胞抗体。它们接受同种异体移植。细胞合作实验表明，[具体小鼠]的免疫缺陷可通过缺乏胸腺来源的细胞群来解释。
