先天性无胸腺小鼠的免疫反应。I. 对恶唑酮无反应。
Immune responses in congenitally thymus-less mice. I. Absence of response to oxazolone.
作者信息
Pritchard H, Micklem H S
出版信息
Clin Exp Immunol. 1972 Jan;10(1):151-61.
Abstract
Cell proliferation in regional lymph nodes of mice sensitized with oxazolone was measured by uptake of IUdR. Experimental factors affecting incorporation of IUdR into lymph nodes are described. The delayed hypersensitivity response was assessed by measuring the increase in ear thickness after subsequent challenge with oxazolone. Unlike normal mice, thymus-less nude' mice showed no detectable response to oxazolone. Implantation of an allogeneic neonatal thymus, either subcutaneously or under the kidney capsule, adoptively conferred on nude' mice the ability to mount a lymphoproliferative response.
摘要
通过碘脱氧尿苷（IUdR）摄取量来测定用恶唑酮致敏的小鼠局部淋巴结中的细胞增殖情况。描述了影响IUdR掺入淋巴结的实验因素。通过测量随后用恶唑酮激发后耳厚度的增加来评估迟发型超敏反应。与正常小鼠不同，无胸腺的“裸”鼠对恶唑酮未表现出可检测到的反应。将同种异体新生胸腺皮下或肾被膜下植入，可使“裸”鼠获得产生淋巴细胞增殖反应的能力。
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