先天性无胸腺小鼠的免疫反应。I. 对恶唑酮无反应。
Immune responses in congenitally thymus-less mice. I. Absence of response to oxazolone.
作者信息
Pritchard H, Micklem H S
出版信息
Clin Exp Immunol. 1972 Jan;10(1):151-61.
Abstract
Cell proliferation in regional lymph nodes of mice sensitized with oxazolone was measured by uptake of IUdR. Experimental factors affecting incorporation of IUdR into lymph nodes are described. The delayed hypersensitivity response was assessed by measuring the increase in ear thickness after subsequent challenge with oxazolone. Unlike normal mice, thymus-less nude' mice showed no detectable response to oxazolone. Implantation of an allogeneic neonatal thymus, either subcutaneously or under the kidney capsule, adoptively conferred on nude' mice the ability to mount a lymphoproliferative response.
摘要
通过碘脱氧尿苷（IUdR）摄取量来测定用恶唑酮致敏的小鼠局部淋巴结中的细胞增殖情况。描述了影响IUdR掺入淋巴结的实验因素。通过测量随后用恶唑酮激发后耳厚度的增加来评估迟发型超敏反应。与正常小鼠不同，无胸腺的“裸”鼠对恶唑酮未表现出可检测到的反应。将同种异体新生胸腺皮下或肾被膜下植入，可使“裸”鼠获得产生淋巴细胞增殖反应的能力。
相似文献
1
Immune responses in congenitally thymus-less mice. I. Absence of response to oxazolone.
Clin Exp Immunol. 1972 Jan;10(1):151-61.
2
Hexamita and Giardia as a cause of mortality in congenitally thymus-less (nude) mice.
Clin Exp Immunol. 1973 Dec;15(4):623-7.
3
Influence of cutaneous sensitization with oxazolone on recruitment of myelogenous stem cells in the thymus.
Clin Exp Immunol. 1972 Sep;12(1):103-10.
4
Immunological responses of 'nude' mice.
Clin Exp Immunol. 1971 Feb;8(2):305-17.
5
The morphology of immune reactions in normal, thymectomized and reconstituted mice. II. The response to oxazolone.
Immunology. 1969 Jul;17(1):111-26.
6
The cellular basis of immunological recovery in nude mice after thymus grafting.
Immunology. 1974 Apr;26(4):769-76.
7
The adrenals and gonads of congenitally thymusless nude mice.
J Endocrinol. 1973 Jul;58(1):vii.
8
Immune responses in mice with murine leprosy.
Clin Exp Immunol. 1970 Jan;6(1):117-24.
9
Hereditary immunodeficiency and leukemogenesis in HRS-J mice.
Cancer Res. 1974 Jan;34(1):201-11.
引用本文的文献
1
Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis.
Immunity. 2011 Oct 28;35(4):562-71. doi: 10.1016/j.immuni.2011.07.013. Epub 2011 Oct 6.
2
[Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 1. Experiments to test the feasibility of combined chemotherapy with VCR and 5-FU (author's transl)].
J Cancer Res Clin Oncol. 1980;96(3):269-79. doi: 10.1007/BF00408099.
3
Age-related changes in cell localization and proliferation in lymph nodes and spleen after antigenic stimulation.
Immunology. 1980 Aug;40(4):687-94.
4
Lymphocyte reactivity contributes to protection conferred by specific antibody passively transferred to herpes simplex virus-infected mice.
Infect Immun. 1980 Aug;29(2):642-9. doi: 10.1128/iai.29.2.642-649.1980.
5
Effect of selected immunoregulatory agents on low-grade contact sensitivity.
Inflammation. 1982 Mar;6(1):55-62. doi: 10.1007/BF00910719.
6
7
Effect of corticosteroids and adult thymectomy on induction and recall of contact sensitivity in mice.
Clin Exp Immunol. 1972 Apr;10(4):661-72.
8
Competition between skin-sensitizing chemicals in the mouse.
Immunology. 1974 Jul;27(1):125-31.
9
10
Characteristics of immunological memory in mice. I. Separate early generation of cells mediating IgM and IgG memory to sheep erythrocytes.
J Exp Med. 1974 Aug 1;140(2):333-48. doi: 10.1084/jem.140.2.333.
本文引用的文献
1
Immunological unresponsiveness of genetically thymusless (nude) mice.
Eur J Immunol. 1971 Jan;1(1):59-61. doi: 10.1002/eji.1830010114.
2
Strain variation in mortality and runt disease in mice thymectomized at birth.
Plast Reconstr Surg. 1962 Apr;29:102-4.
3
A HISTOLOGICAL AND AUTORADIOGRAPHIC STUDY OF LYMPH NODES DURING THE DEVELOPMENT OF CONTACT SENSITIVITY IN THE GUINEA-PIG.
Br J Exp Pathol. 1965 Apr;46(2):147-54.
4
[HEREDITARY THYMIC HYPOPLASIA: ITS PLACE AND RESPONSIBILITY IN A CASE OF LYMPHOCYTIC, NORMOPLASMOCYTIC AND NORMOGLOBULINEMIC APLASIA IN AN INFANT].
Arch Fr Pediatr. 1964 Oct;21:897-920.
5
6
Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth on reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte.
J Exp Med. 1962 Aug 1;116(2):177-86. doi: 10.1084/jem.116.2.177.
7
'Nude', a new hairless gene with pleiotropic effects in the mouse.
Genet Res. 1966 Dec;8(3):295-309. doi: 10.1017/s0016672300010168.
8
The mitotic response of thymus-derived cells to antigenic stimulus.
Transplantation. 1966 Jul;4(4):438-51. doi: 10.1097/00007890-196607000-00008.
9
Changes in the thymus-dependent areas of lymph nodes after immunological stimulation.
Nature. 1966 Dec 17;212(5068):1316-7. doi: 10.1038/2121316a0.
10
The effect of antigen dosage on the response of adoptively transferred cells.
Immunology. 1965 Jun;8(6):549-56.
Zotero 插件