Serviço de Ginecologia e Obstetrícia do Centro Hospitalar de Vila Nova de Gaia e Espinho, Portugal.
Serviço de Nefrologia do Centro Hospitalar de Vila Nova de Gaia e Espinho, Portugal.
J Bras Nefrol. 2021 Jan-Mar;43(1):88-102. doi: 10.1590/2175-8239-JBN-2020-0055.
Pregnancy requires several physiological adaptations from the maternal organism, including modifications in the glomerular filtration rate and renal excretion of several products. Chronic kidney disease (CKD) can negatively affect these modifications and consequently is associated with several adverse maternal and fetal adverse outcomes (gestational hypertension, progression of renal disease, pre-eclampsia, fetal growth restriction, and preterm delivery). A multidisciplinary vigilance of these pregnancies is essential in order to avoid and/or control the harmful effects associated with this pathology. Dialysis and transplantation can decrease the risks of maternal and fetal complications, nonetheless, the rates of complications remain high comparing with a normal pregnancy. Several recent developments in this area have improved quality and efficacy of treatment of pregnant women with CKD. This article summarizes the most recent literature about CKD and pregnancy.
妊娠需要母体组织的多种生理适应，包括肾小球滤过率和多种产物的肾排泄的改变。慢性肾脏病（CKD）可对这些改变产生负面影响，因此与多种不良的母婴结局（妊娠期高血压、肾脏病进展、子痫前期、胎儿生长受限和早产）相关。为了避免和/或控制与该病理学相关的有害影响，对这些妊娠进行多学科监测至关重要。透析和移植可以降低母婴并发症的风险，但与正常妊娠相比，并发症的发生率仍然较高。该领域的一些新进展提高了 CKD 孕妇治疗的质量和效果。本文总结了关于 CKD 和妊娠的最新文献。
