Long intergenic non-coding RNA LINC00485 exerts tumor-suppressive activity by regulating miR-581/EDEM1 axis in colorectal cancer.

Long non-coding RNAs (lncRNA) play a vital role in colorectal cancer (CRC) progression. To investigate the role of long intergenic non-coding RNA in CRC, we performed functional experiments. LoVo tumor-bearing and liver metastasis mice were used as models. We found that expression was significantly lower in CRC tissues and cancer cells than in paired normal samples and human normal colonic epithelial cells. Lower expression of predicted poor prognosis in CRC patients. knockdown promoted the proliferation, migration, and invasion of FHC cells, while overexpression weakened these abilities of LoVo cells. MicroRNA was the downstream target of , which was downregulated in CRC samples and cancer cells compared to normal tissues and normal colonic epithelial cells. overexpression induced proliferation, migration, and invasion of FHC cells, while antagomir treatment produced opposite results. directly targeted the 3'UTR of and inhibited its expression and induction of epithelial-mesenchymal transition of CRC. In mouse models, knockdown or down-regulation of significantly repressed CRC cell growth and prevented CRC liver metastasis. Overall, suppressed CRC tumorigenesis and progression by targeting the / axis. may be a potential therapeutic target for CRC.