Private practice, Chengdu, China.
Private practice, Tientsin, China.
J Biol Regul Homeost Agents. 2021 Jan-Feb;35(1 Suppl. 1):47-54.
Gingivitis and periodontitis (GP) are the main diseases of the oral cavity. The ethiology of GP have never been completely understood, however, loss of balance between the host immune system and the microbial virulence of GP pathogens may be considered the trigger of GP. In fact, the immune system, activated by microbiological agents, attacks the host and not the biofilm bacteria, causing the destruction of periodontal tissue, alveolar bone, and loss of teeth. Parasites may play an important role in the pathology of GP. The first studied and the most common parasite in the oral cavity is Entamoeba gingivalis. A possible link between E. gingivalis and GP has never been demonstrated completely, however E. gingivalis is infrequently found in people without GP. In addition, there is evidence that E. gingivalis could favour the onset and progression of GP. In conclusion, we can assert that E. gingivalis and GP may be correlated. This relationship can open new therapeutical approaches for treating GP, particularly in cases refractory to therapy.
牙龈炎和牙周炎（GP）是口腔的主要疾病。尽管 GP 的病因尚未完全了解，但宿主免疫系统与 GP 病原体的微生物毒力之间的失衡可能被认为是 GP 的触发因素。事实上，免疫系统受到微生物的激活，攻击宿主而不是生物膜细菌，导致牙周组织、牙槽骨破坏和牙齿丧失。寄生虫可能在 GP 的病理学中发挥重要作用。口腔中第一个被研究和最常见的寄生虫是牙龈内阿米巴（Entamoeba gingivalis）。虽然 E. gingivalis 与 GP 之间的可能联系尚未完全证实，但它在没有 GP 的人中很少被发现。此外，有证据表明 E. gingivalis 可能有利于 GP 的发生和进展。总之，我们可以断言 E. gingivalis 和 GP 可能相关。这种关系为治疗 GP 开辟了新的治疗方法，特别是在对治疗有抵抗力的情况下。
