Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
Department of Clinical and Experimental Medicine, University of Foggia, Italy.
J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 1):143-7.
Periodontal disease (PD) is one of the prevalent diseases in the adult population. The ethiology of PD has never been completely understood, however, loss of balance between the host immune system and the microbial virulence of PD pathogens may be considered the trigger of PD. In fact, the immune system, activated by microbiological agents, attacks the host and not the biofilm bacteria, causing the destruction of periodontal tissue, alveolar bone and loss of teeth. Parasites may play an important role in the pathology of PD. The first studied and the most common parasite in the oral cavity is Entamoeba gingivalis. A possible link between E. gingivalis and PD has never been demonstrated completely, however E. gingivalis is infrequently found in people without PD. In addition, there is evidence that E. gingivalis could favour the onset and progression of PD. In conclusion, we can assert that E. gingivalis and PD may be correlated. This relationship can open new therapeutical approaches for treating PD, particularly in cases refractory to therapy.
牙周病（PD）是成年人中常见的疾病之一。PD 的病因从未被完全理解，然而，宿主免疫系统和 PD 病原体的微生物毒力之间的平衡丧失可能被认为是 PD 的触发因素。事实上，免疫系统被微生物激活后会攻击宿主而不是生物膜细菌，导致牙周组织、牙槽骨破坏和牙齿丧失。寄生虫可能在 PD 的病理学中起重要作用。第一个被研究且在口腔中最常见的寄生虫是牙龈内阿米巴（Entamoeba gingivalis）。虽然 E. gingivalis 与 PD 之间的联系从未被完全证实，但在没有 PD 的人群中很少发现 E. gingivalis。此外，有证据表明 E. gingivalis 可能有利于 PD 的发生和发展。总之，我们可以断言 E. gingivalis 和 PD 可能相关。这种关系为治疗 PD 开辟了新的治疗方法，特别是在对治疗有抗药性的情况下。
