Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg Germany.
Chair of Technology Management, FAU Erlangen-Nürnberg, Dr.-Mack-Str. 81, 90762 Fürth, Germany.
ACS Biomater Sci Eng. 2020 May 11;6(5):2709-2725. doi: 10.1021/acsbiomaterials.9b01712. Epub 2020 Apr 13.
Today epidemics of infectious diseases occur more often and spread both faster and further due to globalization and changes in our lifestyle. One way to meet these biological threats are so-called "Frugal Innovations", which focus on the development of affordable, rapid, and easy-to-use diagnostics with widespread use. In this context, point-of-care-tests (POCTs), performed at the patient's bedside, reduce extensive waiting times and unnecessary treatments and enable effective containment measures. This Perspective covers advances in POCT diagnostics on the basis of frugal innovation characteristics that will enable a faster, less expensive, and more convenient reaction to upcoming epidemics. Established POCT systems on the health care market, as well as currently evolving technological advancements in that sector are discussed. Progress in POCT technology and insights on how to most effectively use them allows the handling of more patients in a shorter time frame and consequently improves clinical outcomes at lower cost.
如今，由于全球化和生活方式的改变，传染病的流行更加频繁，传播速度更快、范围更广。应对这些生物威胁的方法之一是所谓的“节俭创新”，其专注于开发负担得起、快速且易于使用的诊断方法，以便广泛应用。在这种情况下，床边即时检测（POCT）可以减少广泛的等待时间和不必要的治疗，并能够采取有效的遏制措施。本文从节俭创新的角度综述了 POCT 诊断的进展，这些进展将能够对即将发生的传染病做出更快、更经济、更方便的反应。本文讨论了已在医疗保健市场上确立的 POCT 系统以及该领域目前正在发展的技术进步。POCT 技术的进步以及如何最有效地利用这些技术的见解使得在更短的时间内可以处理更多的患者，从而以更低的成本改善临床结果。
