Takino Jun-Ichi, Sato Takuma, Hiraishi Isamu, Nagamine Kentaro, Hori Takamitsu
Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
Faculty of Health Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
Biology (Basel). 2021 Jan 14;10(1):57. doi: 10.3390/biology10010057.
The prognosis of pancreatic cancer is considerably worse than that of other cancers, as early detection of pancreatic cancer is difficult and due to its hypovascular environment, which involves low blood flow and a low supply of oxygen and nutrients. Moreover, pancreatic cancer demonstrates a mechanism that allows it to survive in a hypovascular environment. However, the detailed mechanism remains elusive. Recently, it has been reported that heterogeneous ribonuclear protein M (HNRNPM) is a splicing factor associated with malignant tumors. Thus, in this study, we investigated the expression and effects of HNRNPM in pancreatic ductal adenocarcinoma (PDA). We observed that HNRNPM expression, which is highly expressed in pancreatic tissues, was reduced in PDA tissues. Additionally, knockdown of HNRNPM under low-glucose conditions that mimic a hypovascular environment was shown to alter glucose metabolism and prolong cell survival by suppressing glucose consumption. These results suggest that the decreased expression of HNRNPM in PDA may be involved in its adaptation to a hypovascular environment.
胰腺癌的预后比其他癌症要差得多，这是因为胰腺癌很难早期发现，且其血管生成不足，即血流量低，氧气和营养物质供应少。此外，胰腺癌表现出一种使其能在血管生成不足的环境中存活的机制。然而，具体机制仍不清楚。最近有报道称，异质性核糖核蛋白M（HNRNPM）是一种与恶性肿瘤相关的剪接因子。因此，在本研究中，我们调查了HNRNPM在胰腺导管腺癌（PDA）中的表达及作用。我们观察到，HNRNPM在胰腺组织中高表达，而在PDA组织中表达降低。此外，在模拟血管生成不足环境的低糖条件下敲低HNRNPM，结果显示可通过抑制葡萄糖消耗来改变葡萄糖代谢并延长细胞存活时间。这些结果表明，PDA中HNRNPM表达降低可能与其适应血管生成不足的环境有关。
