World Trade Center Health Program, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Washington, DC 20201, USA.
Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Int J Environ Res Public Health. 2021 Jan 14;18(2):681. doi: 10.3390/ijerph18020681.
The terrorist attacks on 11 September 2001 potentially exposed more than 400,000 responders, workers, and residents to psychological and physical stressors, and numerous hazardous pollutants. In 2011, the World Trade Center Health Program (WTCHP) was mandated to monitor and treat persons with 9/11-related adverse health conditions and conduct research on physical and mental health conditions related to the attacks. Emerging evidence suggests that persons exposed to 9/11 may be at increased risk of developing mild cognitive impairment. To investigate further, the WTCHP convened a scientific workshop that examined the natural history of cognitive aging and impairment, biomarkers in the pathway of neurodegenerative diseases, the neuropathological changes associated with hazardous exposures, and the evidence of cognitive decline and impairment in the 9/11-exposed population. Invited participants included scientists actively involved in health-effects research of 9/11-exposed persons and other at-risk populations. Attendees shared relevant research results from their respective programs and discussed several options for enhancements to research and surveillance activities, including the development of a multi-institutional collaborative research network. The goal of this report is to outline the meeting's agenda and provide an overview of the presentation materials and group discussion.
2001 年 9 月 11 日的恐怖袭击可能使超过 40 万名救援人员、工人和居民接触到心理和身体压力源以及大量危险污染物。2011 年，世界贸易中心健康计划（WTCHP）的任务是监测和治疗与 9/11 相关的不良健康状况的人员，并开展与袭击有关的身心健康状况的研究。新出现的证据表明，接触 9/11 的人可能面临发生轻度认知障碍的风险增加。为了进一步调查，WTCHP 召开了一次科学研讨会，该研讨会研究了认知衰老和障碍的自然史、神经退行性疾病途径中的生物标志物、与危险暴露相关的神经病理学变化以及暴露于 9/11 的人群中认知能力下降和障碍的证据。受邀参加者包括积极参与 9/11 暴露人员和其他高危人群健康影响研究的科学家。与会者分享了各自项目的相关研究结果，并讨论了增强研究和监测活动的几种选择，包括建立一个多机构合作研究网络。本报告的目的是概述会议的议程，并概述演示材料和小组讨论的概况。
