Ono S, Toyokura Y, Mannen T, Ishibashi Y
Department of Neurology, Teikyo University School of Medicine, Ichihara Hospital, Japan.
J Neurol Sci. 1988 Jan;83(1):81-92. doi: 10.1016/0022-510x(88)90022-6.
We examined specimens of skin overlying the sacral region, among the most common sites of bedsores, from patients with amyotrophic lateral sclerosis (ALS) and controls, and found that in ALS patients, collagen fibrils had a greater density and became more tightly packed with the duration of illness. Our results suggest that the increased density of collagen fibrils may protect the skin of ALS patients from pressure ischemia, a major cause of bedsore formation.
我们检查了肌萎缩侧索硬化症（ALS）患者和对照组骶骨区域上方的皮肤标本，骶骨区域是褥疮最常见的部位之一，发现ALS患者的胶原纤维密度更大，且随着病程延长变得更加紧密排列。我们的结果表明，胶原纤维密度增加可能会保护ALS患者的皮肤免受压力性缺血影响，压力性缺血是褥疮形成的主要原因。
