Ono S, Yamauchi M
Department of Neurology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan.
J Neurol Sci. 1993 Oct;119(1):74-8. doi: 10.1016/0022-510x(93)90193-3.
The diameter of collagen fibrils and the age-related, stable cross-link, histidinohydroxylysinonorleucine (HHL), of skin tissue (left biceps) were measured and compared in 11 patients with amyotrophic lateral sclerosis (ALS) and 7 controls. In ALS patients, it was found that (1) the diameter of collagen fibrils and the content of HHL were negatively and significantly associated with the duration of illness (r = -0.74, P < 0.01 and r = -0.72, P < 0.02, respectively), and (2) there was an appreciable positive correlation between the diameter of collagen fibrils and the content of HHL (r = 0.73, P < 0.02). These findings were not observed in controls. These suggest there is a close relationship between the decreased amount of HHL and the small diameter of collagen fibrils in ALS.
在11例肌萎缩侧索硬化症（ALS）患者和7名对照者中，测量并比较了皮肤组织（左二头肌）中胶原纤维的直径以及与年龄相关的稳定交联物——组氨酸羟基赖氨酰正亮氨酸（HHL）。在ALS患者中，发现：（1）胶原纤维直径和HHL含量与病程呈显著负相关（r = -0.74，P < 0.01和r = -0.72，P < 0.02）；（2）胶原纤维直径与HHL含量之间存在显著正相关（r = 0.73，P < 0.02）。在对照者中未观察到这些结果。这些表明，ALS中HHL含量降低与胶原纤维直径变小之间存在密切关系。
