Liu Lumei, Stephens Brooke, Bergman Maxwell, May Anne, Chiang Tendy
Center of Regenerative Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.
College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Bioengineering (Basel). 2021 Jan 16;8(1):13. doi: 10.3390/bioengineering8010013.
Collagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease. Thus, understanding how collagen affects healthy airway tissue mechanics is essential. The impact of abnormal collagen deposition and tissue stiffness has been an area of interest in pulmonary diseases such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In this review, we discuss (1) the role of collagen in airway mechanics, (2) macro- and micro-scale approaches to quantify airway mechanics, and (3) pathologic changes associated with collagen deposition in airway diseases. These studies provide important insights into the role of collagen in airway mechanics. We summarize their achievements and seek to provide biomechanical clues for targeted therapies and regenerative medicine to treat airway pathology and address airway defects.
胶原蛋白是气道细胞外基质中含量最丰富的成分，也是气道力学特性的主要决定因素。气道胶原蛋白异常沉积与气道疾病的发病机制和进展相关。因此，了解胶原蛋白如何影响健康气道组织力学至关重要。胶原蛋白异常沉积和组织硬度的影响一直是囊性纤维化、哮喘和慢性阻塞性肺疾病等肺部疾病研究的一个热点领域。在本综述中，我们讨论了（1）胶原蛋白在气道力学中的作用，（2）量化气道力学的宏观和微观方法，以及（3）气道疾病中与胶原蛋白沉积相关的病理变化。这些研究为胶原蛋白在气道力学中的作用提供了重要见解。我们总结了它们的成果，并试图为治疗气道病理和解决气道缺陷的靶向治疗和再生医学提供生物力学线索。
