Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/OC-163, 1060 Vienna, Austria.
Institute of Chemical Engineering, research area Biochemical Engineering, TU Wien, Gumpendorfer Strasse 1a, 1060 Vienna, Austria.
Trends Biotechnol. 2021 Sep;39(9):875-889. doi: 10.1016/j.tibtech.2020.12.009. Epub 2021 Jan 16.
Recently, several studies have proven the potential of cyanobacteria as whole-cell biocatalysts for biotransformation. Compared to heterotrophic hosts, cyanobacteria show unique advantages thanks to their photoautotrophic metabolism. Their ability to use light as energy and CO as carbon source promises a truly sustainable production platform. Their photoautotrophic metabolism offers an encouraging source of reducing power, which makes them attractive for redox-based biotechnological purposes. To exploit the full potential of these whole-cell biocatalysts, cyanobacterial cells must be considered in their entirety. With this emphasis, this review summarizes the latest developments in cyanobacteria research with a strong focus on the benefits associated with their unique metabolism. Remaining bottlenecks and recent strategies to overcome them are evaluated for their potential in future applications.
最近，有几项研究证明了蓝藻作为全细胞生物催化剂进行生物转化的潜力。与异养宿主相比，蓝藻由于其光合作用代谢而具有独特的优势。它们利用光作为能源和 CO2 作为碳源的能力有望提供一个真正可持续的生产平台。它们的光合作用代谢提供了一种有吸引力的还原力来源，这使它们成为基于氧化还原的生物技术应用的理想选择。为了充分利用这些全细胞生物催化剂，必须从整体上考虑蓝藻细胞。基于这一重点，本综述总结了蓝藻研究的最新进展，重点介绍了与其独特代谢相关的益处。还评估了克服这些剩余瓶颈的最新策略在未来应用中的潜力。
