• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
LncRNA EWSAT1 Promotes Colorectal Cancer Progression Through Sponging miR-326 to Modulate FBXL20 Expression.长链非编码RNA EWSAT1通过海绵化miR-326调节FBXL20表达促进结直肠癌进展。
Onco Targets Ther. 2021 Jan 13;14:367-378. doi: 10.2147/OTT.S272895. eCollection 2021.
2
Increased EWSAT1 expression promotes cell proliferation, invasion and epithelial-mesenchymal transition in colorectal cancer.EWSAT1 表达增加促进结直肠癌细胞增殖、侵袭和上皮间质转化。
Eur Rev Med Pharmacol Sci. 2018 Oct;22(20):6801-6808. doi: 10.26355/eurrev_201810_16146.
3
Long non-coding RNA EWSAT1 contributes to the proliferation and invasion of glioma by sponging miR-152-3p.长链非编码RNA EWSAT1通过吸附miR-152-3p促进胶质瘤的增殖和侵袭。
Oncol Lett. 2020 Aug;20(2):1846-1854. doi: 10.3892/ol.2020.11716. Epub 2020 Jun 9.
4
Long non-coding RNA EWSAT1 promoted metastasis and actin cytoskeleton changes via miR-24-3p sponging in osteosarcoma.长非编码 RNA EWSAT1 通过海绵吸附 miR-24-3p 促进骨肉瘤转移和肌动蛋白细胞骨架改变。
J Cell Mol Med. 2021 Jan;25(2):716-728. doi: 10.1111/jcmm.16121. Epub 2020 Nov 22.
5
LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.长链非编码 RNA EWSAT1 通过 miR-330-5p 上调 CPEB4 促进宫颈癌的发展。
Mol Cell Biochem. 2020 Aug;471(1-2):177-188. doi: 10.1007/s11010-020-03778-8. Epub 2020 Jun 17.
6
LncRNA EWSAT1 Promotes Colorectal Cancer Progression Through Sponging miR-326 to Modulate FBXL20 Expression [Retraction].长链非编码RNA EWSAT1通过海绵化miR-326调节FBXL20表达促进结直肠癌进展[撤回]
Onco Targets Ther. 2023 Oct 20;16:845-846. doi: 10.2147/OTT.S445558. eCollection 2023.
7
LncRNA EWSAT1 promotes ovarian cancer progression through targeting miR-330-5p expression.长链非编码RNA EWSAT1通过靶向miR-330-5p的表达促进卵巢癌进展。
Am J Transl Res. 2017 Sep 15;9(9):4094-4103. eCollection 2017.
8
Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p.长链非编码RNA EWSAT1通过靶向miR-326/-330-5p促进人鼻咽癌细胞的体外生长。
Aging (Albany NY). 2016 Nov 3;8(11):2948-2960. doi: 10.18632/aging.101103.
9
LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis.长链非编码 RNA EWSAT1 通过调节 miR-330-5p/ITGA5 轴调控 NSCLC 的肿瘤发生。
Biochem Genet. 2021 Dec;59(6):1441-1456. doi: 10.1007/s10528-021-10069-4. Epub 2021 Apr 29.
10
LncRNA TTN-AS1 sponges miR-376a-3p to promote colorectal cancer progression via upregulating KLF15.长链非编码 RNA TTN-AS1 通过海绵吸附 miR-376a-3p 促进结直肠癌细胞的进展，上调 KLF15。
Life Sci. 2020 Mar 1;244:116936. doi: 10.1016/j.lfs.2019.116936. Epub 2019 Oct 11.

引用本文的文献

1
Circulating long non-coding RNA acts as a liquid biopsy marker for esophageal squamous cell carcinoma: A pilot study.循环长链非编码RNA作为食管鳞状细胞癌的液体活检标志物：一项初步研究。
Noncoding RNA Res. 2023 Oct 28;9(1):1-11. doi: 10.1016/j.ncrna.2023.10.009. eCollection 2024 Mar.
2
Computational identification and clinical validation of a novel risk signature based on coagulation-related lncRNAs for predicting prognosis, immunotherapy response, and chemosensitivity in colorectal cancer patients.基于凝血相关 lncRNAs 的新型风险标志物的计算识别和临床验证，用于预测结直肠癌患者的预后、免疫治疗反应和化疗敏感性。
Front Immunol. 2023 Oct 19;14:1279789. doi: 10.3389/fimmu.2023.1279789. eCollection 2023.
3

本文引用的文献

1
LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.长链非编码 RNA EWSAT1 通过 miR-330-5p 上调 CPEB4 促进宫颈癌的发展。
Mol Cell Biochem. 2020 Aug;471(1-2):177-188. doi: 10.1007/s11010-020-03778-8. Epub 2020 Jun 17.
2
LncRNA TUG1 promotes the progression of colorectal cancer via the miR-138-5p/ZEB2 axis.长链非编码 RNA TUG1 通过 miR-138-5p/ZEB2 轴促进结直肠癌的进展。
Biosci Rep. 2020 Jun 26;40(6). doi: 10.1042/BSR20201025.
3
Colorectal cancer statistics, 2020.2020 年结直肠癌统计数据。
MiR-326 regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis.
miR-326 调控类风湿关节炎成纤维样滑膜细胞的增殖和凋亡。
Hum Cell. 2023 May;36(3):987-996. doi: 10.1007/s13577-023-00873-y. Epub 2023 Feb 7.
4
Aberrant promoter hypermethylation of miR-335 and miR-145 is involved in breast cancer PD-L1 overexpression.miR-335 和 miR-145 的启动子异常高甲基化参与乳腺癌 PD-L1 的过表达。
Sci Rep. 2023 Jan 18;13(1):1003. doi: 10.1038/s41598-023-27415-8.
5
Zooming in on Long Non-Coding RNAs in Ewing Sarcoma Pathogenesis.聚焦尤文肉瘤发病机制中的长链非编码 RNA。
Cells. 2022 Apr 8;11(8):1267. doi: 10.3390/cells11081267.
6
Clinicopathological and prognostic significance of long non-coding RNA EWSAT1 in human cancers: A review and meta analysis.长链非编码 RNA EWSAT1 在人类癌症中的临床病理和预后意义：综述和荟萃分析。
PLoS One. 2022 Mar 14;17(3):e0265264. doi: 10.1371/journal.pone.0265264. eCollection 2022.
7
Long non-coding RNA AC087388.1 as a novel biomarker in colorectal cancer.长链非编码 RNA AC087388.1 作为结直肠癌的新型生物标志物。
BMC Cancer. 2022 Feb 21;22(1):196. doi: 10.1186/s12885-022-09282-0.
8
The Landscape of Regulatory Noncoding RNAs in Ewing's Sarcoma.尤因肉瘤中调控性非编码RNA的格局
Biomedicines. 2021 Jul 31;9(8):933. doi: 10.3390/biomedicines9080933.
9
Unraveling Immune-Related lncRNAs in Breast Cancer Molecular Subtypes.解析乳腺癌分子亚型中与免疫相关的长链非编码RNA
Front Oncol. 2021 May 31;11:692170. doi: 10.3389/fonc.2021.692170. eCollection 2021.
CA Cancer J Clin. 2020 May;70(3):145-164. doi: 10.3322/caac.21601. Epub 2020 Mar 5.
4
LncRNA LINC00461 Promotes Colorectal Cancer Progression via miRNA-323b-3p/NFIB Axis.长链非编码RNA LINC00461通过miRNA-323b-3p/核因子I B轴促进结直肠癌进展。
Onco Targets Ther. 2019 Dec 17;12:11119-11129. doi: 10.2147/OTT.S228798. eCollection 2019.
5
LncRNA CCAT1 Promotes Colorectal Cancer Tumorigenesis Via A miR-181b-5p/TUSC3 Axis.长链非编码RNA CCAT1通过miR-181b-5p/TUSC3轴促进结直肠癌的肿瘤发生。
Onco Targets Ther. 2019 Nov 5;12:9215-9225. doi: 10.2147/OTT.S216718. eCollection 2019.
6
The carcinogenic complex lncRNA DUXAP8/EZH2/LSD1 accelerates the proliferation, migration and invasion of colorectal cancer.致癌复合长链非编码RNA DUXAP8/EZH2/LSD1促进结直肠癌的增殖、迁移和侵袭。
J BUON. 2019 Sep-Oct;24(5):1830-1836.
7
SNHG14 promotes the tumorigenesis and metastasis of colorectal cancer through miR-32-5p/SKIL axis.SNHG14 通过 miR-32-5p/SKIL 轴促进结直肠癌细胞的发生和转移。
In Vitro Cell Dev Biol Anim. 2019 Dec;55(10):812-820. doi: 10.1007/s11626-019-00398-5. Epub 2019 Aug 30.
8
LncRNA KCNQ1OT1 controls cell proliferation, differentiation and apoptosis by sponging miR-326 to regulate c-Myc expression in acute myeloid leukemia.长链非编码 RNA KCNQ1OT1 通过海绵吸附 miR-326 调控 c-Myc 表达来控制急性髓系白血病细胞增殖、分化和凋亡。
Neoplasma. 2020 Mar;67(2):238-248. doi: 10.4149/neo_2018_181215N972. Epub 2019 Aug 4.
9
The lncRNA TDRG1 promotes cell proliferation, migration and invasion by targeting miR-326 to regulate MAPK1 expression in cervical cancer.长链非编码RNA TDRG1通过靶向miR-326调控丝裂原活化蛋白激酶1（MAPK1）的表达，从而促进宫颈癌细胞的增殖、迁移和侵袭。
Cancer Cell Int. 2019 May 31;19:152. doi: 10.1186/s12935-019-0872-4. eCollection 2019.
10
Long noncoding RNA SBF2-AS1 promotes colorectal cancer proliferation and invasion by inhibiting miR-619-5p activity and facilitating HDAC3 expression.长链非编码 RNA SBF2-AS1 通过抑制 miR-619-5p 的活性和促进 HDAC3 的表达促进结直肠癌细胞的增殖和侵袭。
J Cell Physiol. 2019 Aug;234(10):18688-18696. doi: 10.1002/jcp.28509. Epub 2019 Mar 25.

长链非编码RNA EWSAT1通过海绵化miR-326调节FBXL20表达促进结直肠癌进展。

LncRNA EWSAT1 Promotes Colorectal Cancer Progression Through Sponging miR-326 to Modulate FBXL20 Expression.

作者信息

Liu Jing, Huang Shimei, Liao Xin, Chen Zhongsheng, Li Lianghe, Yu Lei, Zhan Wei, Li Rui

机构信息

Imaging Department, Affiliated Hospital of Guizhou Medical University, Guiyang, People's Republic of China.

Forensic Clinical Teaching and Research Office, Guizhou Medical University, Guiyang, People's Republic of China.

出版信息

Onco Targets Ther. 2021 Jan 13;14:367-378. doi: 10.2147/OTT.S272895. eCollection 2021.

DOI:10.2147/OTT.S272895
PMID:33469313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7812937/
Abstract

BACKGROUND

Ewing sarcoma-associated transcript 1 () has been reported to be a pivotal modulator in a series of cancers. However, the function of in colorectal cancer (CRC) has not been elaborated. This study aimed to explore the role of in CRC progression and the underlying mechanisms.

METHODS

The expression patterns of , and were examined by qCRCR. Si-EWSAT1 was transfected to study the effects of on cell proliferation and metastasis. Rescue experiments were performed to investigate the underlying mechanisms in vitro. Xenograft models were used to evaluate the role of in vivo.

RESULTS

We found that was highly expressed in CRC tissues and cell lines and associated with poor overall survival. In vitro, knockdown of suppressed the cell proliferation, migration and invasion. Moreover, miR-326 was found to be a target of , and inhibitor could partially reverse the effects on CRC cell progression induced by si-EWSAT1. Subsequently, we validated as a vital downstream target for , and positively regulated via in vitro. In addition, these findings were confirmed by in vivo experiments.

CONCLUSION

Taken together, the data showed that promoted CRC progression via targeting pathway, which might provide a novel therapeutic target for CRC treatment.

摘要

背景

据报道，尤因肉瘤相关转录本1（EWSAT1）在一系列癌症中是关键调节因子。然而，EWSAT1在结直肠癌（CRC）中的功能尚未阐明。本研究旨在探讨EWSAT1在CRC进展中的作用及其潜在机制。

方法

通过qCRCR检测EWSAT1、miR-326和ZEB1的表达模式。转染Si-EWSAT1以研究EWSAT1对细胞增殖和转移的影响。进行挽救实验以体外研究潜在机制。使用异种移植模型在体内评估EWSAT1的作用。

结果

我们发现EWSAT1在CRC组织和细胞系中高表达，且与总体生存率差相关。在体外，敲低EWSAT1可抑制细胞增殖、迁移和侵袭。此外，发现miR-326是EWSAT1的靶标，miR-326抑制剂可部分逆转si-EWSAT1对CRC细胞进展的影响。随后，我们验证ZEB1是EWSAT1的重要下游靶标，且EWSAT1在体外通过miR-326正向调节ZEB1。此外，体内实验证实了这些发现。

结论

综上所述，数据表明EWSAT1通过靶向miR-326/ZEB1途径促进CRC进展，这可能为CRC治疗提供新的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/a757c4b445e3/OTT-14-367-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/44bc0d0f0c35/OTT-14-367-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/69674f06dc2c/OTT-14-367-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/d267106f0fb1/OTT-14-367-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/0c0d190adc8a/OTT-14-367-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/c4681e49d970/OTT-14-367-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/3426faf9bb31/OTT-14-367-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/a757c4b445e3/OTT-14-367-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/44bc0d0f0c35/OTT-14-367-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/69674f06dc2c/OTT-14-367-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/d267106f0fb1/OTT-14-367-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/0c0d190adc8a/OTT-14-367-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/c4681e49d970/OTT-14-367-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/3426faf9bb31/OTT-14-367-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf56/7812937/a757c4b445e3/OTT-14-367-g0007.jpg