Department of Translational Medicine, Molecular Genetic Reproductive Medicine, Clinical Research Centre, Lund University, Malmo, Sweden.
Department of Translational Medicine, Reproductive Medicine Centre, Skåne University Hospital, Lund University, Malmo, Sweden.
J Cancer Surviv. 2023 Feb;17(1):101-109. doi: 10.1007/s11764-021-00987-y. Epub 2021 Jan 19.
Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals' health and mental life. The objective of this study was to investigate health state and well-being among female CCS with and without POI and healthy controls (HC).
Female CCS treated in southern Sweden between 1964 and 2008 were included. Each patient was matched with a HC. The final study population included 167 female CCS and 164 HC that were examined between October 2010 and January 2015 at the Reproductive Medicine Centre at Skåne University Hospital in Malmö, Sweden. All participants, except for two HCs, answered an EQ-5D-3L questionnaire for measuring health state including a visual analogue scale (VAS) for estimating well-being.
There were 22 CCS with POI, none of the HC had POI. The mean health state differed among groups (unadjusted: P = 0.002; adjusted: P = 0.007). A difference in mean experienced well-being among groups was noted (unadjusted: P = 0.003; adjusted: P = 0.012). Lowest well-being was found in the CCS group with POI (P = 0.024).
Female CCS have a significantly decreased health state and well-being. Female CCS with POI additionally have the lowest self-estimated well-being.
Female CCS with POI should be identified early in order to give them adequate information and support.
由于生存时间延长，儿童癌症幸存者（CCS）的人数不断增加。然而，女性CCS在癌症治疗后有发生卵巢早衰（POI）的风险。POI 会降低受孕机会，而这种不孕状态对受影响个体的健康和精神生活有重大影响。本研究的目的是调查有无 POI 的女性 CCS 与健康对照者（HC）的健康状况和幸福感。
纳入在瑞典南部接受治疗的 1964 年至 2008 年间的女性 CCS。每位患者均与一名 HC 匹配。最终的研究人群包括 167 名女性 CCS 和 164 名 HC，他们于 2010 年 10 月至 2015 年 1 月在瑞典马尔默斯科讷大学医院生殖医学中心接受检查。除了两名 HC 外，所有参与者都回答了 EQ-5D-3L 问卷，以测量健康状况，包括用于评估幸福感的视觉模拟量表（VAS）。
有 22 名 CCS 患有 POI，而 HC 中无一例患有 POI。各组之间的健康状况均值存在差异（未经调整：P = 0.002；调整后：P = 0.007）。各组之间的幸福感均值也存在差异（未经调整：P = 0.003；调整后：P = 0.012）。POI 组的幸福感最低（P = 0.024）。
女性 CCS 的健康状况和幸福感显著下降。患有 POI 的女性 CCS 额外存在最低的自我估计幸福感。
应尽早识别出患有 POI 的女性 CCS，以便为她们提供充分的信息和支持。
