Lastrucci Luciana, Bertocci Silvia, Bini Vittorio, Borghesi Simona, De Majo Roberta, Rampini Andrea, Pernici Paola, Gennari Pietro Giovanni
Unit of Radiation Oncology, San Donato Hospital, Arezzo, Italy.
Department of Medicine Section of Internal Medicine Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy.
Radiol Med. 2017 Apr;122(4):303-308. doi: 10.1007/s11547-016-0722-6. Epub 2017 Jan 9.
To analyze quality of life (QoL) and functional state (FS) by patient-reported outcome (PRO) questionnaires (FACT-G, FACT-NP, PSS-HN, XeQOLS, and EQ-5D-3L) in long-term survivors nasopharyngeal carcinoma (NPC) treated with conventional radiotherapy (RT) and intensity modulated radiotherapy (IMRT).
25 patients answered to five questionnaires about QoL and FS. All patients were assessed also for late toxicity.
Functional Assessment of Cancer Therapy-General (FACT-G) and Performance Status Scale Head and Neck (PSS-HN) scores were significantly elevated (better QoL) in age <50 years (p = 0.03). PSS-HN score was higher in IMRT group. The observed xerostomia was lower in the IMRT group and in patients who received conventional RT had worse QoL according to XeQOLS (University of Michigan Xerostomia-Related Quality of Life Scale) score questionnaire. Lower PSS-HN score and higher XeQOLS score were significantly related with the late xerostomia (p = 0.009 and 0.002, respectively).
Our preliminary data suggest that age, older techniques, xerostomia, and hearing loss are negative predictors of QoL.
通过患者报告结局（PRO）问卷（FACT-G、FACT-NP、PSS-HN、XeQOLS和EQ-5D-3L）分析接受传统放疗（RT）和调强放疗（IMRT）的鼻咽癌（NPC）长期幸存者的生活质量（QoL）和功能状态（FS）。
25名患者回答了关于QoL和FS的五份问卷。所有患者还接受了晚期毒性评估。
年龄<50岁的患者癌症治疗通用功能评估（FACT-G）和头颈部性能状态量表（PSS-HN）得分显著升高（生活质量更好）（p = 0.03）。IMRT组的PSS-HN得分更高。根据XeQOLS（密歇根大学口干相关生活质量量表）得分问卷，IMRT组观察到的口干情况较少，接受传统放疗的患者生活质量较差。较低的PSS-HN得分和较高的XeQOLS得分与晚期口干显著相关（分别为p = 0.009和0.002）。
我们的初步数据表明，年龄、较旧的技术、口干和听力损失是生活质量的负面预测因素。
