肌肉功能低下对印度尼西亚系统性红斑狼疮女性患者健康相关生活质量的影响。

The impact of low muscle function on health-related quality of life in Indonesian women with systemic lupus erythematosus.

机构信息

Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.

Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.

出版信息

Lupus. 2021 Apr;30(4):680-686. doi: 10.1177/0961203320988595. Epub 2021 Jan 20.

DOI:10.1177/0961203320988595

PMID:33470149

Abstract

OBJECTIVE

There was no study aimed at evaluating the effect of muscle function on SLE patients' quality of life using the Sarcopenia Quality of Life (SarQoL) questionnaire.

METHODS

This cross-sectional study recruited 61 women with SLE consecutively, muscle function was measured with Jamar handheld-dynamometer and 6-meter walk test, HRQoL was measured with Sarcopenia Quality of Life (SarQoL) questionnaire. The cut-off point for low muscle strength (<18 kg) and low gait speed (<1.0 m/s) was according to the Asian Working Group on Sarcopenia 2019 criteria. Statistical analysis was conducted with a t-test for mean difference, and linear regression was used to adjust confounders (age, protein intake, physical exercise, and disease activity).

RESULTS

The subjects' mean muscle strength was 19.54 kg (6.94), and 44.3% (n = 27) was found to have low muscle strength. The subjects' mean gait speed was 0.77 m/s (0.20), and 90.3% (n = 55) was found to have low gait speed. The difference of total SarQoL score in subjects with normal and low muscle strength was found to be significant; 74.86 (9.48) vs. 65.49 (15.51) (p = 0.009), and still statistically significant after adjustments with age, protein intake, physical exercise level, and disease activity [B 0.56; 95% CI 0.08-1.03; p = 0.022]. The difference of total SarQoL score in subjects with normal and low physical performance was found to be not significant, 70.67 (11.08) vs. 70.72 (13.56) (p = 0.993).

CONCLUSION

There was a significant difference in SarQoL's total score in normal compared with low muscle strength groups of Indonesian women with SLE.

摘要

目的

目前尚无研究使用肌少症生存质量问卷（SarQoL）评估肌肉功能对系统性红斑狼疮（SLE）患者生活质量的影响。

方法

本横断面研究连续招募了 61 名女性 SLE 患者，使用 Jamar 手持测力计和 6 米步行试验测量肌肉功能，使用 SarQoL 问卷测量 HRQoL。低肌肉力量（<18kg）和低步态速度（<1.0m/s）的截断值根据 2019 年亚洲肌少症工作组标准。采用 t 检验进行均值差异比较，线性回归调整混杂因素（年龄、蛋白质摄入、体育锻炼和疾病活动度）。

结果

受试者的平均肌肉力量为 19.54kg（6.94），44.3%（n=27）的肌肉力量较低。受试者的平均步态速度为 0.77m/s（0.20），90.3%（n=55）的步态速度较慢。肌肉力量正常和较低的受试者的 SarQoL 总分差异有统计学意义；74.86（9.48）vs.65.49（15.51）（p=0.009），调整年龄、蛋白质摄入、体育锻炼水平和疾病活动度后仍有统计学意义[B 0.56；95%CI 0.08-1.03；p=0.022]。肌肉力量正常和较低的受试者 SarQoL 总分差异无统计学意义，70.67（11.08）vs.70.72（13.56）（p=0.993）。