VCA SouthPaws Veterinary Specialists & Emergency, 8500 Arlington Blvd, Fairfax, VA, 22031, USA.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp St., Columbus, OH, 43210, USA.
Vet Dermatol. 2021 Apr;32(2):148-e35. doi: 10.1111/vde.12921. Epub 2021 Jan 20.
Conventional therapy for canine acral lick dermatitis (ALD) consists of systemic antibiotics and anti-anxiety medications. Low-level laser therapy (LLLT) is a noninvasive therapy used to treat inflammatory and painful conditions.
HYPOTHESIS/OBJECTIVES: The primary objective was to determine whether LLLT with conventional therapy would be beneficial as an adjunct treatment for ALD. We hypothesized that LLLT and conventional therapy combined would result in a greater reduction in licking Visual Analog Score (LVAS) compared to conventional therapy alone. Secondary objectives were to assess change in lesion/ulcer size, thickness and hair growth.
Thirteen dogs with a skin lesion consistent with ALD.
Dogs were randomly assigned to two groups. All dogs received systemic antibiotics and trazodone. The treatment group (TG) received LLLT by laser (130 mW, 2 min) with blue and red light-emitting diodes (LEDs), while the control group (CG) had sham therapy (laser/LEDs off). Treatments were administered three times weekly for two weeks, then twice weekly for two weeks for a total of 10 visits. Descriptive statistics were performed (mean, median); primary and secondary objectives were assessed with nonparametric ANOVA (Kruskal-Wallis test), with significance set at P < 0.05.
Thirteen dogs (six CG, seven TG) were enrolled. There were no significant differences in median LVAS, lesion/ulcer size or thickness of the ALD lesion between TG and CG. There was a significantly greater increase (24%) in hair growth in TG (P = 0.0081) compared to CG.
Treatment of ALD requires multimodal therapy. Although combining LLLT with conventional therapy did not result in a significantly greater reduction in LVAS, there was a significant increase in hair growth compared to conventional therapy alone.
犬肢端舔舐性皮炎（ALD）的常规治疗包括全身抗生素和抗焦虑药物。低水平激光疗法（LLLT）是一种非侵入性治疗方法，用于治疗炎症和疼痛性疾病。
假设/目的：主要目的是确定 LLLT 联合常规疗法是否可作为 ALD 的辅助治疗方法有益。我们假设 LLLT 和常规疗法联合使用会比单独使用常规疗法导致舔舐视觉模拟评分（LVAS）更大的降低。次要目标是评估病变/溃疡大小、厚度和毛发生长的变化。
13 只皮肤病变符合 ALD 的犬。
将狗随机分配到两组。所有狗均接受全身抗生素和曲唑酮治疗。治疗组（TG）接受激光（130 mW，2 分钟）和蓝、红光发光二极管（LED）的 LLLT，而对照组（CG）则接受假治疗（激光/LED 关闭）。治疗每周进行三次，持续两周，然后每周两次，共进行 10 次治疗。采用描述性统计（平均值、中位数）；使用非参数 ANOVA（Kruskal-Wallis 检验）评估主要和次要目标，显著性水平设为 P < 0.05。
共纳入 13 只狗（6 只 CG，7 只 TG）。TG 和 CG 之间的 ALD 病变 LVAS、病变/溃疡大小或厚度中位数无显著差异。与 CG 相比，TG 中毛发生长增加（24%）（P = 0.0081）有显著意义。
ALD 的治疗需要多模式治疗。尽管将 LLLT 与常规疗法联合使用并未导致 LVAS 显著降低，但与单独使用常规疗法相比，毛发生长有显著增加。
