Social-emotional, sleep and feeding problems in young patients with agenesis of the corpus callosum and the life quality of their parents.

Agenesis of the corpus callosum (ACC) is a common congenital brain malformation. Most patients with no combined abnormalities have a good prognosis, but impairments have been observed in their sleep, feeding, and higher-order cognitive functions. Sixty-three Chinese ACC patients, aged 0-3 years, were included in our cross-sectional online research. The Chinese version of Infant-Toddler Social and Emotional Assessment (ITESA), the Brief Infant Sleep Questionnaire (BISQ), and the Montreal Children's Hospital Feeding Scale (MCH-FS) were used to assess these patients. We also used the brief version of the World Health Organization's Quality of Life Instrument (WHOQOL-BREF) to evaluate their parents. 43% of patients had ITESA domain problem: 10% in Externalizing, 7% in Internalizing, 3% in Dysregulation, and 30% in Competence. 52% of the patients were rated by their parents as having a sleep problem. Feeding difficulties occurred in 23% of patients. Patients' sleep and feeding problems were significantly correlated with their social and emotional performance, which influenced the life quality of their parents. Patients with intracranial abnormalities had more internalizing problems. In conclusion, sleep and feeding problems in young ACC patients might indicate their social-emotional problems. The problems in ACC patients were correlated with the life quality of their parents.