Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Neuropediatrics. 2021 Apr;52(2):142-145. doi: 10.1055/s-0040-1721701. Epub 2021 Jan 20.
Toxocarosis is the consequence of human infection by spp. larvae and is one of the most common ascarioses, not only in developing countries, but also in the European region, where its prevalence reaches 14%. Due to their particular behavior, children are at higher risk of this parasitic infection, whose clinical features depend on the localization of the larvae. Neurotoxocariasis is very uncommon in children and may take different forms depending on the underlying physiopathologic process: immune reaction against the parasite antigens, vasculitis, treatment complications, or, very rarely, brain localization of spp. larvae. The association between neurotoxocariasis and the onset of childhood epilepsy has been postulated but is still debated. Moreover, a spp. abscess causing epileptic seizures in children has been rarely described, especially in western countries. Hereby we present a 9-year-old patient with a new diagnosis of epilepsy definitely secondary to brain abscess due to the localization of larvae. Diagnosis was confirmed by neuroimaging and serological test. The successful treatment with albendazole and steroids was documented with a close and long-term clinical and neuroradiological follow-up. Our experience confirms that every case of cryptogenetic epilepsy in children deserves a neuroimaging study and, in case of cystic images, serology is mandatory to avoid further unnecessary invasive diagnostic investigations and to set the specific drug therapy.
旋毛虫病是人类感染 spp.幼虫的后果,是最常见的类圆线虫病之一,不仅在发展中国家,而且在欧洲地区也很常见,其患病率达到 14%。由于儿童的特殊行为,他们更容易感染这种寄生虫病,其临床特征取决于幼虫的定位。神经旋毛虫病在儿童中非常罕见,根据潜在的病理生理过程可能有不同的表现形式:对寄生虫抗原的免疫反应、血管炎、治疗并发症,或者非常罕见的情况下, spp.幼虫在大脑中的定位。神经旋毛虫病与儿童癫痫发作之间的关联已被提出,但仍存在争议。此外,儿童中由 spp.幼虫引起的脓肿导致癫痫发作的情况很少见,尤其是在西方国家。在此,我们报告了一例 9 岁患儿,新诊断为癫痫,明确继发于脑脓肿,原因是幼虫的定位。通过神经影像学和血清学检查确诊。阿苯达唑和类固醇的成功治疗与密切和长期的临床和神经影像学随访一起记录在案。我们的经验证实,每个患有隐源性癫痫的儿童都应进行神经影像学检查,如果出现囊性图像,必须进行 血清学检查,以避免进一步进行不必要的侵入性诊断检查,并确定特定的药物治疗。