King A J, Hutchings M E, Moore D R, Blakemore C
University Laboratory of Physiology, Oxford, UK.
Nature. 1988 Mar 3;332(6159):73-6. doi: 10.1038/332073a0.
Environmental factors play an important role in certain aspects of the development of sensory systems. But the way in which the maturation of different sensory modalities is coordinated is poorly understood. We have investigated this question neurophysiologically in the mammalian superior colliculus (SC), which contains topographically aligned maps of visual and auditory space. We report here that an essentially normal auditory map, in approximate register with the visual map, is found in the SC of adult ferrets reared with abnormal binaural localization cues. Also, if, early in life, one eye is deviated laterally, there is a compensatory shift in the auditory map, but early eye rotation totally disorders the auditory representation. These results imply that development of the auditory map is affected by visual activity or by information about eye position and that there is definite, but limited, capacity for the auditory map to reorganize so that it remains aligned with the visual map.
环境因素在感觉系统发育的某些方面起着重要作用。但不同感觉模态的成熟是如何协调的，目前还知之甚少。我们已在哺乳动物的上丘（SC）中通过神经生理学方法研究了这个问题，上丘包含视觉和听觉空间的拓扑对齐图谱。我们在此报告，在具有异常双耳定位线索的环境中饲养的成年雪貂的上丘中，发现了一个与视觉图谱大致对齐的基本正常的听觉图谱。此外，如果在生命早期一只眼睛向外偏斜，听觉图谱会发生代偿性移位，但早期的眼球旋转会完全扰乱听觉表征。这些结果表明，听觉图谱的发育受视觉活动或眼位信息的影响，并且听觉图谱有一定但有限的重新组织能力，以便与视觉图谱保持对齐。
