Department of Clinical Psychology and Psychotherapy, Institute of Psychology, Faculty of Psychology and Human Movement Science, Universität Hamburg, Hamburg, Germany
Department of Clinical Psychology and Psychotherapy, Institute of Psychology, Faculty of Psychology and Human Movement Science, Universität Hamburg, Hamburg, Germany.
BMJ Open. 2021 Jan 20;11(1):e039777. doi: 10.1136/bmjopen-2020-039777.
Family interventions are effective and are strongly recommended for psychotic disorders. However, there is a variety of intervention types, and their differential efficacy is widely unclear. The aim of the planned network meta-analysis (NMA) is to compare the efficacy of family interventions that differ in content (eg, psychoeducation, mutual support, skills training) and format (eg, number of sessions, inclusion of patients, form of delivery).
We will include randomised controlled trials comparing psychosocial interventions directed at the adult relatives, friends or non-professional carers of people with a diagnosis of a psychotic disorder (schizophrenia spectrum) to any kind of control condition. The main outcomes will be global clinical state for the patients and coping with psychosis as well as attitudes towards psychosis for the relatives. Additional outcomes will be severity of symptoms, functioning, burden and compliance/drop-out. We conducted a comprehensive search of Cochrane Central Register of Controlled Trials, MEDLINE(R), PsycINFO, Cumulative Index to Nursing & Allied Health Literature (8 August 2019) and reference lists of review articles. Full-text assessment of eligibility, data extraction and risk-of-bias assessment will be done by two independent reviewers. An NMA will be conducted for any of the planned outcomes and intervention characteristics for which sufficient and appropriate data are available. The analyses will make use of a random effects model within a frequentist framework. Estimates for all pairwise treatment effects will be obtained using standardised mean differences for continuous outcomes and risk ratios for dichotomous outcomes. Interventions will be ranked according to their relative efficacy. We will address the assumption of transitivity, heterogeneity and inconsistency using theoretical and statistical approaches. The possibility of publication bias and the strength of evidence will also be examined.
There are no ethical concerns. Results will be published in peer-reviewed journals and presented at practitioners' conferences.
CRD42020148728.
家庭干预对于精神障碍是有效的，并且强烈推荐使用。然而，干预的类型多种多样，其疗效差异尚不清楚。本计划网络荟萃分析（NMA）旨在比较不同内容（例如，心理教育、互助、技能培训）和形式（例如，疗程数、患者纳入、传递形式）的家庭干预措施的疗效。
我们将纳入比较针对精神障碍（精神分裂症谱系）患者的成年亲属、朋友或非专业照顾者的心理社会干预与任何对照条件的随机对照试验。主要结局为患者的整体临床状况和对精神疾病的应对，以及亲属对精神疾病的态度。附加结局为症状严重程度、功能、负担和依从性/脱落率。我们对 Cochrane 对照试验中心注册库、MEDLINE（R）、PsycINFO、护理及相关健康文献累积索引（2019 年 8 月 8 日）和综述文章的参考文献进行了全面检索。两名独立评审员将对资格、数据提取和偏倚风险评估进行全面评估。对于任何计划的结局和干预特征，如果有足够和适当的数据，将进行 NMA。分析将在频繁主义框架内使用随机效应模型进行。将使用标准化均数差值进行连续结局和风险比进行二分类结局的治疗效果的所有两两比较估计。干预措施将根据其相对疗效进行排序。我们将使用理论和统计方法解决可传递性、异质性和不一致性的假设。还将检查发表偏倚的可能性和证据的强度。
无伦理问题。结果将发表在同行评议的期刊上，并在从业者会议上展示。
PROSPERO 注册号：CRD42020148728。
