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长上行 propriospinal 神经元为四肢协调提供灵活的、特定于上下文的控制。

Long ascending propriospinal neurons provide flexible, context-specific control of interlimb coordination.

机构信息

Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, United States.

Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States.

出版信息

Elife. 2020 Sep 9;9:e53565. doi: 10.7554/eLife.53565.

DOI:10.7554/eLife.53565
PMID:32902379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7527236/
Abstract

Within the cervical and lumbar spinal enlargements, central pattern generator (CPG) circuitry produces the rhythmic output necessary for limb coordination during locomotion. Long propriospinal neurons that inter-connect these CPGs are thought to secure hindlimb-forelimb coordination, ensuring that diagonal limb pairs move synchronously while the ipsilateral limb pairs move out-of-phase during stepping. Here, we show that silencing long ascending propriospinal neurons (LAPNs) that inter-connect the lumbar and cervical CPGs disrupts left-right limb coupling of each limb pair in the adult rat during overground locomotion on a high-friction surface. These perturbations occurred independent of the locomotor rhythm, intralimb coordination, and speed-dependent (or any other) principal features of locomotion. Strikingly, the functional consequences of silencing LAPNs are highly context-dependent; the phenotype was not expressed during swimming, treadmill stepping, exploratory locomotion, or walking on an uncoated, slick surface. These data reveal surprising flexibility and context-dependence in the control of interlimb coordination during locomotion.

摘要

在颈椎和腰椎的脊髓扩大部位，中枢模式发生器（CPG）电路产生了在运动过程中协调肢体所需的节律性输出。连接这些 CPG 的长固有脊髓神经元被认为可以确保后肢-前肢的协调，确保在对角肢体同步移动的同时，同侧肢体在迈步时异相移动。在这里，我们表明，在高摩擦表面上的地面运动中，沉默连接腰椎和颈椎 CPG 的长升序固有脊髓神经元（LAPN）会破坏成年大鼠每个肢体对的左右肢体耦合。这些干扰与运动节律、肢体内协调以及速度依赖性（或任何其他）运动的主要特征无关。引人注目的是，沉默 LAPN 的功能后果高度依赖于上下文；在游泳、跑步机行走、探索性运动或在未涂层的光滑表面上行走时，没有表现出这种表型。这些数据揭示了在运动过程中控制肢体间协调的惊人的灵活性和上下文依赖性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/c464d0af7611/elife-53565-fig5-figsupp2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/f5d5d4b7387a/elife-53565-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/7f461b08ced6/elife-53565-fig4-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/91c1229b9323/elife-53565-fig4-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/8f8bfc7488fd/elife-53565-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/24267fad828c/elife-53565-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/c464d0af7611/elife-53565-fig5-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/e653a0901211/elife-53565-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/79a0d207f49e/elife-53565-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/8f4a7da20b0a/elife-53565-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/36b88d894b38/elife-53565-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/995766e585c5/elife-53565-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/dafedd769503/elife-53565-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/f5d5d4b7387a/elife-53565-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/7f461b08ced6/elife-53565-fig4-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/91c1229b9323/elife-53565-fig4-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/8f8bfc7488fd/elife-53565-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/24267fad828c/elife-53565-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/7527236/c464d0af7611/elife-53565-fig5-figsupp2.jpg

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