Cystic Fibrosis Reference Center, Gent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
Zeepreventorium, De Haan, Belgium.
Eur J Pediatr. 2021 Jun;180(6):1981-1985. doi: 10.1007/s00431-021-03943-1. Epub 2021 Jan 20.
The pulmonary function of patients with cystic fibrosis (CF) is associated with nutritional status not only expressed as body mass index (BMI) but also as fat-free mass index (FFMI). This study evaluated the effect of a residential rehabilitation program on nutritional status (BMI, FFMI). The rehabilitation program provided supervised respiratory and nutritional treatment and daily physical activity for 3 weeks (median stay 20 (19-25) days). At the start and the end of the program, weight, height, pulmonary function, and body composition using dual-energy X-ray absorptiometry were prospectively collected. Supervised weighed food records were obtained, and physical activity intensity was measured using a SenseWear Pro3 Armband. CF-related complications were collected from the patient. Thirty-four patients (21 males, median age 18 years old (12-27)) were included. The diet contained a median of 30 EN% fat, 16 EN% protein, and 52 EN% of carbohydrates. A significant median weight gain (+1.45 kg (0.58; 2.6) (p < 0.0001) and a significant increase in BMI (+0.24 kg/m (0.11; 0.38)) (p < 0.0001), FFMI (+0.26 kg/m (0.01; 0.55)) (p < 0.0001), and FMI (+0.19 kg/m (0.04; 0.41)) (p < 0.0001) were obtained.Conclusion: A short rehabilitation program in individuals with CF between 6 and 40 years old is able to improve nutritional status and body composition.Trial registration: NCT04527796 What is Known: • Fat-free mass depletion is frequently present in CF. • In CF pulmonary function is associated with nutritional status measured as body mass index but also fat-free mass index. What is New: • Nutritional status and body composition improve significantly after a short-term rehabilitation program. • The rehabilitation program was able to improve nutritional outcome even with a diet containing less fat than currently advised in the guidelines.
囊性纤维化 (CF) 患者的肺功能不仅与身体质量指数 (BMI) 等营养状况有关，还与去脂体重指数 (FFMI) 有关。本研究评估了住宅康复计划对营养状况 (BMI、FFMI) 的影响。该康复计划提供了为期 3 周的监督呼吸和营养治疗以及日常体育活动（中位数停留时间为 20（19-25）天）。在计划开始和结束时，前瞻性收集体重、身高、肺功能和双能 X 射线吸收法测量的身体成分。获得了监督称重的食物记录，并使用 SenseWear Pro3 臂带测量了身体活动强度。从患者处收集了 CF 相关并发症。34 名患者（21 名男性，中位年龄 18 岁（12-27 岁））入选。饮食中含有中位数为 30%的 EN 脂肪、16%的蛋白质和 52%的碳水化合物。体重显著增加（+1.45 公斤（0.58；2.6）（p < 0.0001），BMI 显著增加（+0.24 公斤/米（0.11；0.38））（p < 0.0001），FFMI 显著增加（+0.26 公斤/米（0.01；0.55））（p < 0.0001）和 FMI 显著增加（+0.19 公斤/米（0.04；0.41））（p < 0.0001）。结论：6 至 40 岁 CF 患者的短期康复计划能够改善营养状况和身体成分。试验注册：NCT04527796 已知：• 去脂体重减少在 CF 中很常见。• CF 肺功能与身体质量指数等营养状况有关，但也与去脂体重指数有关。新内容：• 短期康复计划后，营养状况和身体成分显著改善。• 即使饮食中脂肪含量低于目前指南建议，该康复计划仍能改善营养结果。
