School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen518107, China.
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Curr Med Chem. 2021;28(31):6437-6457. doi: 10.2174/0929867328666210121122106.
Photodynamic Therapy (PDT), as a clinically approved modality for the treatment of various disordered diseases including cancer, has received great advances in recent years. By preferentially accumulating non-toxic Photosensitizers (PSs) in the pathological area, and in situ generation of cytotoxic reactive oxygen species (ROS) under local irradiation by a light source with appropriate wavelength, PDT works in a dual-selective manner. Over the past decades, numerous studies and reviews on PDT mainly focused on activable PSs and the newly emerging PSs in PDT. However, to the best of our knowledge, there are few articles on the systematic introduction of light sources and limited reports about targeted strategies in PDT. This review comprehensively summarizes various light sources applied in PDT together with typical enhanced targeting strategies, and outlines their advantages and disadvantages, respectively. The clinical applications and future perspectives in light sources are also partly presented and discussed.
光动力疗法（PDT）作为一种临床认可的治疗各种疾病（包括癌症）的方法，近年来取得了很大进展。PDT 通过在病理区域优先积累无毒的光敏剂（PSs），并在适当波长的光源局部照射下原位生成细胞毒性活性氧（ROS），以双重选择性方式发挥作用。在过去的几十年中，大量关于 PDT 的研究和综述主要集中在可激活 PSs 和 PDT 中新兴的 PSs 上。然而，据我们所知，很少有文章系统介绍 PDT 中的光源，也很少有关于 PDT 中靶向策略的报道。本文全面总结了应用于 PDT 的各种光源以及典型的增强靶向策略，并分别概述了它们的优缺点。还部分介绍和讨论了光源的临床应用和未来展望。
