Instituto Nacional de Salud, Bogota, Colombia.
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Med Virol. 2021 Nov;93(11):6393-6397. doi: 10.1002/jmv.26815. Epub 2021 Feb 1.
We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection.
我们评估了哥伦比亚的母婴巨细胞病毒（CMV）感染情况。在妊娠中位数为 10（四分位距：8-12）周时，对 1501 名孕妇的血清进行了 CMV 免疫球蛋白 G 抗体检测。对婴儿尿液进行 CMV 聚合酶链反应以诊断先天性（≤21 天）和产后（>21 天）感染。母体 CMV 血清阳性率为 98.1%（95%置信区间[CI]：97.5%-98.8%）。先天性 CMV 患病率为每 1000 例活产儿中有 8.4（95%CI：3.9%-18.3%；6/711）例。在随后在 6 个月大时对没有确诊先天性 CMV 感染的 472 名婴儿进行检测中，258 名（54.7%，95%CI：50.2%-59.1%）有产后感染。
