哥伦比亚母婴巨细胞病毒感染的流行病学研究。
Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia.
机构信息
Instituto Nacional de Salud, Bogota, Colombia.
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
J Med Virol. 2021 Nov;93(11):6393-6397. doi: 10.1002/jmv.26815. Epub 2021 Feb 1.
Abstract
We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection.
摘要
我们评估了哥伦比亚的母婴巨细胞病毒（CMV）感染情况。在妊娠中位数为 10（四分位距：8-12）周时，对 1501 名孕妇的血清进行了 CMV 免疫球蛋白 G 抗体检测。对婴儿尿液进行 CMV 聚合酶链反应以诊断先天性（≤21 天）和产后（>21 天）感染。母体 CMV 血清阳性率为 98.1%（95%置信区间[CI]：97.5%-98.8%）。先天性 CMV 患病率为每 1000 例活产儿中有 8.4（95%CI：3.9%-18.3%；6/711）例。在随后在 6 个月大时对没有确诊先天性 CMV 感染的 472 名婴儿进行检测中，258 名（54.7%，95%CI：50.2%-59.1%）有产后感染。
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