School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Analyst. 2021 Sep 27;146(19):5934-5941. doi: 10.1039/d1an01257f.
The rapid fabrication of artificial skin patches with multiple functions has attracted great attention in various research fields, such as personal health monitoring, tissue engineering and robotics. Intertwined-network structures (blood vessel, lymphatic and nerve networks) play a key role in endowing skin with multiple functions. Thus, considerable efforts have been devoted to fabricating artificial skin patches with mimetic internal channels. Here, we present a one-step 3D printed intelligent silk fibroin artificial skin (i-skin) with built-in electronics and microfluidics. By simultaneously extruding functional materials in polyurethane-silk fibroin precursor using a 3D bioprinter, the i-skin and its internal channels can be fabricated within one step. Photonic crystals (PCs) were integrated into the microfluidic channel, enabling the i-skin to sense multiple biomarkers. Moreover, the printed electronics give the i-skin remarkable conductivity, endowing the i-skin with the capability of sensitive motion sensing. Notably, by using the built-in electronics and PC-integrated microfluidics, sensitive sensing of motions and specific cardiac biomarkers can be achieved simultaneously in the i-skin, indicating the remarkable prospects of the printed multi-functional i-skin in health care-related biomedical fields.
具有多种功能的人工皮肤贴片的快速制造引起了各个研究领域的极大关注，如个人健康监测、组织工程和机器人技术。交织网络结构（血管、淋巴管和神经网络）在赋予皮肤多种功能方面起着关键作用。因此，人们付出了相当大的努力来制造具有仿生内部通道的人工皮肤贴片。在这里，我们提出了一种一步 3D 打印智能丝素蛋白人工皮肤（i-skin），具有内置电子设备和微流控系统。通过在 3D 生物打印机中同时挤出聚氨酯-丝素蛋白前体中的功能材料，可以在一步内制造 i-skin 及其内部通道。光子晶体（PCs）被集成到微流道中，使 i-skin 能够感应多种生物标志物。此外，打印的电子设备赋予 i-skin 显著的导电性，使 i-skin 具有灵敏的运动感应能力。值得注意的是，通过内置电子设备和集成 PC 的微流控系统，i-skin 可以同时实现对运动和特定心脏生物标志物的敏感感应，表明打印多功能 i-skin 在与医疗保健相关的生物医学领域具有显著的应用前景。
