肝 X 受体在 T 细胞稳态中的多功能性：位置，位置，位置！

The versatility of liver X receptors in T cell homeostasis: Location, location, location!

机构信息

Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.

出版信息

J Exp Med. 2021 Apr 5;218(4). doi: 10.1084/jem.20202318.

DOI:10.1084/jem.20202318

PMID:33475707

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7829932/

Abstract

Nuclear receptors control the transcriptional program of target cells and thereby their phenotype and activities. Two complementary studies by Micheals et al. (https://doi.org/10.1084/jem.20201311) and Chan et al. (https://doi.org/10.1084/jem.20200318) published in JEM uncover the cell type-specific expression and role of the nuclear receptors liver X receptors in the regulation of T cell homeostasis and function.

摘要

核受体控制靶细胞的转录程序，从而控制其表型和活性。Micheals 等人的两项互补研究（https://doi.org/10.1084/jem.20201311）和 Chan 等人的研究（https://doi.org/10.1084/jem.20200318）发表在《细胞》杂志上，揭示了核受体肝 X 受体在调节 T 细胞动态平衡和功能中的细胞类型特异性表达和作用。