肾脏钠（Na）MRI：基本概念。
Sodium (Na) MRI of the Kidney: Basic Concept.
机构信息
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
The MR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
出版信息
Methods Mol Biol. 2021;2216:257-266. doi: 10.1007/978-1-0716-0978-1_15.
The handling of sodium by the renal system is a key indicator of renal function. Alterations in the corticomedullary distribution of sodium are considered important indicators of pathology in renal diseases. The derangement of sodium handling can be noninvasively imaged using sodium magnetic resonance imaging (Na MRI), with data analysis allowing for the assessment of the corticomedullary sodium gradient. Here we introduce sodium imaging, describe the existing methods, and give an overview of preclinical sodium imaging applications to illustrate the utility and applicability of this technique for measuring renal sodium handling.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.
肾脏系统对钠的处理是肾功能的一个关键指标。皮质-髓质分布的钠变化被认为是肾脏疾病病理的重要指标。钠磁共振成像（Na MRI）可以非侵入性地对钠处理的变化进行成像，数据分析可以评估皮质-髓质钠梯度。在这里，我们介绍了钠成像，描述了现有的方法，并概述了临床前钠成像的应用，以说明该技术测量肾脏钠处理的实用性和适用性。这一章是基于 COST 行动 PARENCHIMA 的工作，这是一个由欧洲科学技术合作组织（COST）计划资助的社区驱动网络，旨在提高肾脏 MRI 生物标志物的重现性和标准化。本介绍章节由另外两章补充，分别描述了实验过程和数据分析。
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