GE Healthcare, Dallas, Texas, USA.
Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Methods Mol Biol. 2021;2216:697-710. doi: 10.1007/978-1-0716-0978-1_42.
Hyperpolarized C MR is a novel medical imaging modality with substantially different signal dynamics as compared to conventional H MR, thus requiring new methods for processing the data in order to access and quantify the embedded metabolic and functional information. Here we describe step-by-step analysis protocols for functional renal hyperpolarized C imaging. These methods are useful for investigating renal blood flow and function as well as metabolic status of rodents in vivo under various experimental physiological conditions.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.
极化 C 磁共振成像是一种新颖的医学成像方式，与传统的 H 磁共振成像相比，其信号动态有很大的不同，因此需要新的方法来处理数据，以获取和量化嵌入的代谢和功能信息。在这里，我们描述了用于功能性肾极化 C 成像的分步分析方案。这些方法可用于在各种实验生理条件下研究体内啮齿动物的肾功能、肾功能和代谢状态。这一章基于 COST 行动 PARENCHIMA 的工作，该行动是一个由欧洲合作科学技术（COST）计划资助的社区驱动网络，旨在提高肾脏 MRI 生物标志物的可重复性和标准化。该分析方案章节由另外两个章节补充，描述了基本概念和实验程序。
