肾脏 MRI 扩散：实验方案。
Renal MRI Diffusion: Experimental Protocol.
机构信息
Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany.
ZTL-Imaging Center, Hannover Medical School, Hannover, Germany.
出版信息
Methods Mol Biol. 2021;2216:419-428. doi: 10.1007/978-1-0716-0978-1_24.
Renal diffusion-weighted imaging (DWI) can be used to obtain information on the microstructure of kidney tissue, and has the potential to provide MR-biomarkers for functional renal imaging. Here we describe in a step-by-step experimental protocol the MRI method for measuring renal diffusion coefficients in rodents using ADC or IVIM models. Both methods provide quantification of renal diffusion coefficients; however, IVIM, a more complex model, allows for the calculation of the pseudodiffusion and fraction introduced by tissue vascular and tubular components. DWI provides information of renal microstructure contributing to the understanding of the physiology and the underlying processes that precede the beginning of pathologies.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.
肾脏弥散加权成像（DWI）可用于获取肾脏组织微观结构信息，有望为功能肾成像提供 MR 生物标志物。本实验步骤描述了使用 ADC 或 IVIM 模型在啮齿动物中测量肾脏弥散系数的 MRI 方法。这两种方法均可定量测量肾脏弥散系数；然而，更复杂的 IVIM 模型允许计算组织血管和管状成分引入的伪扩散和分数。DWI 提供了有关肾脏微观结构的信息，有助于理解生理学和病理发生前的潜在过程。
本章基于 PARENCHIMA 成本行动的工作，这是一个由欧洲科学技术合作组织（COST）计划资助的社区驱动网络，旨在提高肾脏 MRI 生物标志物的重现性和标准化。该实验方案章节由另外两章补充说明，描述了基本概念和数据分析。
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