Robo Céline, Wenner David, Ubhayasekera S J Kumari A, Hilborn Jöns, Öhman-Mägi Caroline, Persson Cecilia
Department of Materials Science and Engineering, Division of Applied Materials Science, Uppsala University, 751 21 Uppsala, Sweden.
Department of Chemistry-BMC, Analytical Chemistry, Uppsala University, 751 23 Uppsala, Sweden.
J Funct Biomater. 2021 Jan 17;12(1):5. doi: 10.3390/jfb12010005.
Acrylic bone cements modified with linoleic acid are a promising low-modulus alternative to traditional high-modulus bone cements. However, several key properties remain unexplored, including the effect of autoclave sterilization and the potential use of low-modulus cements in other applications than vertebral augmentation. In this work, we evaluate the effect of sterilization on the structure and stability of linoleic acid, as well as in the handling properties, glass transition temperature, mechanical properties, and screw augmentation potential of low-modulus cement containing the fatty acid. Neither H NMR nor SFC-MS/MS analysis showed any detectable differences in autoclaved linoleic acid compared to fresh one. The peak polymerization temperature of the low-modulus cement was much lower (28-30 °C) than that of the high-modulus cement (67 °C), whereas the setting time remained comparable (20-25 min). The T of the low-modulus cement was lower (75-78 °C) than that of the high-stiffness cement (103 °C). It was shown that sterilization of linoleic acid by autoclaving did not significantly affect the functional properties of low-modulus PMMA bone cement, making the component suitable for sterile production. Ultimately, the low-modulus cement exhibited handling and mechanical properties that more closely match those of osteoporotic vertebral bone with a screw holding capacity of under 2000 N, making it a promising alternative for use in combination with orthopedic hardware in applications where high-stiffness augmentation materials can result in undesired effects.
用亚油酸改性的丙烯酸骨水泥是一种很有前景的低模量替代传统高模量骨水泥的材料。然而，几个关键特性仍未得到探索，包括高压灭菌的影响以及低模量水泥在椎体强化以外的其他应用中的潜在用途。在这项工作中，我们评估了灭菌对亚油酸结构和稳定性的影响，以及对含脂肪酸的低模量水泥的操作性能、玻璃化转变温度、力学性能和螺钉强化潜力的影响。与新鲜亚油酸相比，核磁共振氢谱（H NMR）和超临界流体色谱-串联质谱（SFC-MS/MS）分析均未显示高压灭菌后的亚油酸有任何可检测到的差异。低模量水泥的峰值聚合温度（28 - 30°C）远低于高模量水泥（67°C），而凝固时间保持相当（20 - 25分钟）。低模量水泥的玻璃化转变温度（75 - 78°C）低于高硬度水泥（103°C）。结果表明，通过高压灭菌对亚油酸进行灭菌不会显著影响低模量聚甲基丙烯酸甲酯（PMMA）骨水泥的功能特性，使其适合无菌生产。最终，低模量水泥表现出的操作和力学性能与骨质疏松性椎体骨更接近，螺钉固定能力低于2000 N，使其成为在高硬度强化材料可能产生不良影响的应用中与骨科硬件联合使用的有前景的替代品。
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